Description
Amlodipine Tablets 5 mg. №30
Ingredients:
Each tablet contains 5 mg of Amlodipine besylate. Inactive ingredients include microcrystalline cellulose, sodium starch glycolate, and magnesium stearate.
Mechanism of Action:
Amlodipine belongs to the class of calcium channel blockers. It inhibits the influx of calcium ions into vascular smooth muscle and cardiac muscle cells, leading to vasodilation and reduced myocardial oxygen demand.
Pharmacological Properties:
Amlodipine is a dihydropyridine calcium channel blocker that selectively inhibits calcium ion influx across cell membranes. It acts primarily on vascular smooth muscle cells and cardiac muscle cells, resulting in vasodilation and decreased myocardial contractility.
Indications for Use:
Amlodipine is indicated for the treatment of hypertension and chronic stable angina. It is effective in lowering blood pressure and improving blood flow through the coronary arteries.
Contraindications:
Do not use Amlodipine if you are allergic to amlodipine or any other dihydropyridine calcium channel blockers. It is contraindicated in patients with severe hypotension, shock, or a history of sensitivity to the drug.
Side Effects:
Common side effects of Amlodipine may include edema, headache, dizziness, fatigue, and flushing. Serious side effects such as hypotension, palpitations, and allergic reactions are rare but possible. Consult your healthcare provider if you experience any adverse effects.
Usage Instructions:
The recommended dosage of Amlodipine is one 5 mg tablet per day. The tablet should be taken orally with or without food. Do not crush or chew the tablet. Follow the prescribed dosage regimen strictly to achieve optimal therapeutic outcomes.
Benefits Compared to Analogues:
Amlodipine has demonstrated superior efficacy in reducing blood pressure and improving cardiac function compared to other antihypertensive agents. Its long-term safety profile and tolerability make it a preferred choice for the management of hypertension and angina.
Suitable Patient Groups:
Amlodipine is suitable for adult patients with hypertension and chronic stable angina. It can also be used in specific patient populations such as the elderly, but dosage adjustments may be necessary based on individual health conditions and response to treatment.
Storage and Shelf Life:
Store Amlodipine tablets in a cool, dry place away from direct sunlight and moisture. Keep the medication out of reach of children. Check the expiration date on the packaging and do not use the tablets beyond the stated shelf life.
Packaging Description:
Amlodipine tablets are typically packaged in blister packs containing 30 tablets per pack. Each tablet is individually sealed to maintain product integrity and ensure dosage accuracy. The packaging should include essential information such as the drug name, strength, and expiration date.
Clinical Evidence and Proven Effectiveness:
Studies have shown that Amlodipine effectively reduces blood pressure and improves cardiac function in patients with hypertension and angina. A meta-analysis published in the Journal of Clinical Hypertension demonstrated the superior efficacy of Amlodipine compared to other antihypertensive agents.
