Ampicillin (ampicillin sodium salt) 1g. vial

The dose of the drug and the duration of treatment should be set individually, depending on the severity of the disease, the location of the infection and the sensitivity of the pathogen to the drug. Administer the drug intramuscularly or intravenously (drip or stream).
The recommended dose for adults is 250-500 mg 4 times a day. Daily up to 1-3 g. In severe infections, the daily dose can be increased to 10 g or more.
For newborns, the drug should be prescribed in a daily dose of 20-40 mg/kg, for children of other age groups – 50-100 mg/kg. In case of a severe course of the infection, the indicated doses may be doubled. The daily dose should be administered in 4-6 doses with an interval of 4-6 hours.
For meningitis in children: children under the age of 1 month should be prescribed in a daily dose of 100-500 mg/kg, children over the age of 1 month should be prescribed in a daily dose of 200-300 mg/kg for 6-8 injections. Administer the daily dose in 4-6 doses.
The duration of treatment is 7-14 days or more. Treatment with ampicillin should be continued for at least 48-72 hours after normalization of body temperature and disappearance of symptoms of the disease. For infections caused by hemolytic streptococcus, the duration of treatment should be at least 10 days.
The solution for intramuscular injection should be prepared immediately before use by adding 5 ml of sterile water for injections to the contents of the vial. For intravenous jet administration, a single dose of the drug (no more than 2 g) should be dissolved in 5-10 ml of water for injections or 0.9% sodium chloride solution and administered slowly over 3-5 minutes (administration of a dose of 1-2 g should be carried out during 10-15 minutes). At a single dose exceeding 2 g, the drug should be administered intravenously. For intravenous drip administration, dissolve a single dose of the drug (2-4 g) in a small volume of water for injections (7.5-15 ml, respectively), then add the resulting antibiotic solution to 125-250 ml of 0.9% sodium solution chloride or 5-10% glucose solution and enter at a rate of 60-80 drops per minute. For drip administration to children, use a 5-10% glucose solution as a solvent.

Ampicillin is used in pediatric practice.

In case of overdose, toxic effects on the central nervous system (dizziness, headache), dyspeptic phenomena (nausea, vomiting, loose stools), allergic reactions in the form of skin rash are possible. In case of symptoms of overdose, the drug should be discontinued immediately and, if necessary, symptomatic treatment should be carried out: gastric lavage, use of activated charcoal, saline laxatives, correction of water-electrolyte balance, hemodialysis. Antihistamines and desensitizing agents are indicated for allergies

From the immune system : allergic reactions, including rash, itching, hyperemia, urticaria, rhinitis, conjunctivitis, rarely – hives, joint pain, eosinophilia, exfoliative dermatitis, purpura, exudative erythema multiforme, Stevens-Johnson syndrome, very rarely – Quincke’s edema, anaphylactic shock.

From the side of the digestive system: nausea, vomiting, diarrhea, changes in taste, abdominal pain, stomatitis, glossitis, dry mouth, intestinal dysbiosis, gastritis, enterocolitis, hemorrhagic colitis. In the course of treatment or for several weeks after the end of antibiotic therapy, there is a possibility of developing pseudomembranous colitis.

From the hepatobiliary system : hepatitis, cholestatic jaundice.

From the side of the central and peripheral nervous system : when using high doses in patients with kidney failure – dizziness, headache, tremor, convulsions, neuropathy.

Local reactions: including swelling, itching, hyperemia at the injection site.

Laboratory indicators: a moderate increase in the activity of “hepatic” transaminases, lactate dehydrogenase, alkaline phosphatase, creatinine, pseudo-positive results of non-enzymatic glucosuric tests and Coombs reaction.

Others: reversible disorders of hematopoiesis (leukopenia, thrombocytopenia, hemolytic anemia, agranulocytosis), interstitial nephritis, superinfection, candidiasis. When using Ampicillin in patients with bacteremia (sepsis), a bacteriolysis reaction (Yarish-Herxheimer reaction) is possible.