Ampicillin (ampicillin) tablets 0.25 №10

active substance : ampicillin;

1 tablet contains ampicillin trihydrate in terms of ampicillin 250 mg;

excipients : potato starch, talc, calcium stearate.

Tablets.

The main physicochemical properties : tablets of white or almost white color, round shape with a flat surface, with a bevel and a line.

Beta-lactam antibiotics, penicillins. Broad-spectrum penicillins.

ATX code J01C A01.

Ampicillin trihydrate has a wide range of antimicrobial activity. Active against gram-positive microorganisms (Streptococcus spp., including S. pneumoniae, Enterococcus spp., etc.) and a number of gram-negative microorganisms (Neisseria meningitidis, N. gonorrhoeae, Escherichia coli, Shigella spp., Salmonella spp., Proteus spp., Bordetella pertussis, some strains of Haemophilus influenzae, etc.). The drug is destroyed by penicillinase and therefore has no effect on penicillinase-producing strains of microbes (for example, Staphylococcus spp.).

It is well absorbed when taken internally, penetrating into the tissues and biological fluids of the body. The drug is not destroyed in the acidic environment of the stomach. When taken internally, the maximum concentration of the drug in the blood is determined after 1.5-2 hours. The time to reduce the concentration of the drug in the blood by half is 60-120 minutes. It is excreted mainly by the kidneys, and high concentrations of the unchanged antibiotic are formed in the urine, and a large amount also enters the bile. Approximately 30% of the applied dose is removed within 6-8 hours, approximately 60% in 24 hours. Ampicillin trihydrate does not accumulate during repeated applications, which makes it possible to use it for a long time in large doses.

Infections caused by microorganisms sensitive to the drug:

• biliary system infections (cholangitis, cholecystitis);
• infections of the respiratory tract and ENT organs (pneumonia, bronchitis, lung abscess, sinusitis, pharyngitis, otitis, tonsillitis);
• meningitis;
• gastroenteritis caused by shigella or salmonella, typhoid and paratyphoid;
• bacterial endocarditis;
• infections of the genitourinary system (pyelitis, pyelonephritis, cystitis, urethritis, gonorrhea);
• peritonitis;
• septicemia;
• skin and soft tissue infections.

1. Increased sensitivity to ampicillin and other β-lactam antibiotics (penicillins, cephalosporins, carbapenems), as well as to any auxiliary components of the drug.
2. Severe disorders of liver function.
3. Infectious mononucleosis.
4. Leukemia.
5. HIV infection.

Use Ampicillin tablets as prescribed by a doctor. Ampicillin tablets should be administered orally 30 minutes before or 2 hours after a meal. The duration of treatment with ampicillin is set individually (from 5 days to 3 weeks or more), depending on the characteristics of the disease, the patient’s age, the effectiveness of therapy and the state of kidney function. After the disappearance of clinical signs of the disease, ampicillin should be taken for another 2-3 days.

The recommended single standard dose for adults and children over 14 years of age is 250-1000 mg every 6 hours. The dosage regimen is established by the doctor.

Urinary tract infections: 500 mg every 8 hours.

Typhoid and paratyphoid: 1000-2000 mg every 6 hours. With an acute course of the disease – within 2 weeks, if the patient is a bacillus carrier – 4-12 weeks.

Uncomplicated gonorrhea: a single dose of 2000 mg of ampicillin in combination with 1000 mg of probenecid. It is recommended to repeat the course of treatment in women.

Infections of the respiratory tract and ENT organs: 250 mg every 6 hours.

Pneumonia: 500 mg every 6 hours.

Children over 6 years of age should be prescribed the drug in a daily dose of 100 mg/kg of body weight. The daily dose should be divided into 4-6 doses.

Patients with severe renal dysfunction (creatinine clearance less than 10 ml/min) need to adjust the dosage regimen: the dose of the drug should be reduced or the interval between doses should be increased.

Ampicillin tablets should not be used in children under 6 years of age.

In case of overdose, toxic effects on the central nervous system (dizziness, headache), dyspeptic phenomena (nausea, vomiting, loose stools), allergic reactions in the form of skin rash are possible. In case of symptoms of overdose, the drug should be discontinued immediately and, if necessary, symptomatic treatment should be carried out: gastric lavage, use of activated charcoal, saline laxatives, correction of water-electrolyte balance, hemodialysis. Antihistamines and desensitizing agents are indicated for allergies.