Description

Ampril (Ramipril) HD tablets 5 mg/25 mg. №30

Ingredients

Each tablet contains 5 mg of Ramipril and 25 mg of Hydrochlorothiazide.

Dosage

The usual recommended dose is one tablet daily. It is important to follow the instructions provided by your healthcare provider.

Indications

Ampril HD tablets are indicated for the treatment of hypertension. It is used when blood pressure is not adequately controlled by either ramipril or hydrochlorothiazide alone.

Contraindications

Do not use Ampril HD tablets if you are allergic to any of the ingredients, have a history of angioedema related to previous ACE inhibitor therapy, or have severe renal impairment.

Directions

Take one tablet daily with or without food, as directed by your healthcare provider. It is important to continue taking this medication even if you feel well.

Scientific Evidence

Ramipril, an ACE inhibitor, and hydrochlorothiazide, a diuretic, work synergistically to lower blood pressure. Studies have shown that the combination of these two medications is more effective in reducing blood pressure compared to monotherapy. Research published in the Journal of Hypertension demonstrated that the combination of ramipril and hydrochlorothiazide led to a significant reduction in both systolic and diastolic blood pressure levels.

Additional Information

It is important to monitor blood pressure regularly while taking Ampril HD tablets. Some common side effects may include dizziness, cough, and electrolyte imbalances. If you experience any severe side effects, contact your healthcare provider immediately.

Pharmacological Effects: Ramipril works by inhibiting the angiotensin-converting enzyme, leading to vasodilation and reduced aldosterone secretion. Hydrochlorothiazide acts on the kidneys to increase the excretion of sodium and water, reducing blood volume and lowering blood pressure.

Clinical Trials: Clinical trials have shown that the combination of ramipril and hydrochlorothiazide is well-tolerated and effective in the management of hypertension. A study published in the American Journal of Medicine found that the combination therapy resulted in a greater reduction in blood pressure compared to ramipril alone.