$6.00
Manufacturer: Ukraine
Anesthetic, antipyretic, antispasmodic (acts on the smooth muscles of the urinary and biliary tract) drugs of the group of pyrazolone derivatives. The anti-inflammatory effect is weakly expressed.
The mechanism of action is due to the inhibition of cyclooxygenase, which leads to a decrease in the synthesis of prostaglandins, which cause the development of pain in the focus of inflammation, an increase in temperature and an increase in tissue permeability, as well as a violation of the conduction of pain extra and proprioceptive impulses, an increase in the excitability threshold of thalamic pain sensitivity centers, and an increase in heat transfer.
Description
Analgin (metamizole sodium) ampoules 50% 2 ml. №10
Ingredients
active ingredient: 1 ml of solution contains metamizole sodium 500 mg;
excipients: sodium metabisulphite (E 223), Trilon B, sodium formaldehyde sulfoxylates, sodium hydroxide, water for injection.
Dosage form
Injection.
Basic physical and chemical properties: transparent colorless or yellowish solution.
Pharmacotherapeutic group
Analgesics and antipyretics. Metamizole sodium. ATX code N02B B02.
Pharmacodynamics
Anesthetic, antipyretic, antispasmodic (acts on the smooth muscles of the urinary and biliary tract) drugs of the group of pyrazolone derivatives. The anti-inflammatory effect is weakly expressed.
The mechanism of action is due to the inhibition of cyclooxygenase, which leads to a decrease in the synthesis of prostaglandins, which cause the development of pain in the focus of inflammation, an increase in temperature and an increase in tissue permeability, as well as a violation of the conduction of pain extra and proprioceptive impulses, an increase in the excitability threshold of thalamic pain sensitivity centers, and an increase in heat transfer.
Pharmacokinetics
After administration, metamizole is hydrolyzed to an active metabolite (when administered intravenously, unchanged metamizole is found in blood plasma in small quantities). Communication of an active metabolite with proteins – 50-60%. Metabolized in the liver, excreted by the kidneys. Penetrates through the placental barrier and into breast milk.
Indications
Pain syndrome of low and medium intensity of various origin and localization (headache, toothache, burns, pain in the postoperative period, dysmenorrhea, arthralgia, neuralgia, radiculitis, myositis) hyperthermic syndrome, febrile conditions (with influenza, acute respiratory and other infections) renal and hepatic colic (in combination with antispasmodics).
Contraindications
Hypersensitivity to metamizole sodium, to other pyrazolone derivatives or other components of the drug. Attacks of bronchial asthma caused by acetylsalicylic acid. Violation of hematopoiesis (agranulocytosis, cytostatic or infectious neutropenia). Liver and/or kidney failure. Hereditary hemolytic anemia associated with deficiency of glucose-6-phosphate dehydrogenase. Suspicion of acute surgical pathology. Anemia, leukopenia. Kidney disease pyelonephritis, glomerulonephritis, including history. Do not administer to patients with systolic blood pressure below 100 mm Hg. Art. Polytrauma. Shock. Porfiry.
Dosage and administration
Assign intramuscularly and intravenously by jet. The route of administration and dose depend on the severity of the disease and are determined individually. The analgesic effect with intravenous administration is higher than with intravenous administration.
Analgin (metamizole sodium) ampoules 50% solution that is injected must be at body temperature. To prevent a sharp decrease in blood pressure, the introduction should be carried out slowly (at a rate of no more than 1 ml / min), the patient should be in the supine position, control of blood pressure, heart rate and respiration is necessary. The procedure requires the availability of conditions for anti-shock therapy. When administered intravenously, a long needle must be used.
Adults are prescribed 0.5-1 ml (250-500 mg) 2-3 times a day. The maximum single dose for both routes of administration is 1 ml (500 mg), daily – 2 ml (1 g).
Children under the age of 1 year should be prescribed at a dose of 0.01 ml / kg of body weight.
For children under the age of 1 year, the drug should be administered only intramuscularly.
Duration of application – up to 3 days.
For children over 1 year of age, administer 0.1 ml for 1 year of life 1-2 times a day. Duration of application – up to 3 days.
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