Description
Anastrozol SAN (Anastrozole) Doses Coated Tablets 1 mg. №28
Composition
Anastrozol SAN tablets contain 1 mg of anastrozole as the active ingredient. The inactive ingredients include lactose, povidone, sodium starch glycolate, magnesium stearate, hypromellose, macrogol, and titanium dioxide.
Mechanism of Action
Anastrozole, the active ingredient in Anastrozol SAN tablets, is a selective non-steroidal aromatase inhibitor. It works by inhibiting the enzyme aromatase, thereby reducing the production of estrogen, which plays a key role in the growth of hormone receptor-positive breast cancer cells.
Pharmacological Properties
As an aromatase inhibitor, anastrozole exerts its pharmacological effects by blocking the conversion of androgens to estrogens. This action leads to decreased estrogen levels in postmenopausal women, contributing to the inhibition of tumor growth in hormone receptor-positive breast cancer.
Indications for Use
Anastrozol SAN is indicated for the adjuvant treatment of hormone receptor-positive early breast cancer in postmenopausal women. It is also approved for the treatment of advanced breast cancer in postmenopausal women who have not responded adequately to other therapies such as tamoxifen.
Contraindications
Avoid using Anastrozol SAN if you have a known allergy to anastrozole or any of the tablet components. This medication is contraindicated in premenopausal women and individuals with a history of hypersensitivity reactions to aromatase inhibitors.
Side Effects
Common side effects of Anastrozol SAN tablets may include hot flashes, joint pain, fatigue, nausea, and bone thinning (osteoporosis). Rare but serious side effects can include an increased risk of cardiovascular events and musculoskeletal disorders. Consult your healthcare provider if you experience any adverse reactions.
Usage Instructions
For optimal results, take Anastrozol SAN tablets orally once daily, with or without food. The recommended dose is 1 mg per day. Swallow the tablet whole with a glass of water. If a dose is missed, take it as soon as possible unless it is close to the next scheduled dose.
Benefits Over Analogues
Compared to other aromatase inhibitors, anastrozole has shown superior efficacy in reducing the risk of cancer recurrence and improving disease-free survival in postmenopausal women with early breast cancer. Its favorable side effect profile and convenient once-daily dosing make it a preferred choice for many patients.
Suitable Patient Groups
Anastrozol SAN is specifically recommended for postmenopausal women with hormone receptor-positive breast cancer. It is not indicated for use in premenopausal women or men. Elderly patients may require dose adjustments based on their overall health status and renal function.
Storage and Shelf Life
Store Anastrozol SAN tablets in a cool, dry place away from direct sunlight and moisture. Keep the blister pack sealed until ready for use. Check the expiration date on the packaging and do not use the tablets if past the expiry date.
Packaging Description
Anastrozol SAN tablets are supplied in blister packs containing 28 coated tablets. Each tablet is imprinted with the dosage strength for easy identification. The packaging is designed to protect the tablets from environmental factors and maintain their stability.
Clinical Evidence and Effectiveness
Clinical studies have demonstrated the efficacy of anastrozole in reducing the risk of cancer recurrence and improving overall survival in postmenopausal women with hormone receptor-positive early breast cancer. The drug has also shown significant benefits in the treatment of advanced breast cancer, leading to better disease control and quality of life.
