Antistrumin (potassium iodide) tablets 1 mg. №100

active ingredient: potassium iodide;

1 tablet contains: potassium iodide 1 mg;

excipients: crystalline sugar, calcium stearate.

Pills.

Basic physical and chemical properties : tablets of white or almost white color with a yellowish tint, flat-cylindrical shape with a chamfer.

Iodine preparations used in diseases of the thyroid gland. ATX code H03C A.

Iodine is a vital trace element that is part of the thyroid hormones – thyroxine (T4) and triiodothyronine (T3), which ensures its normal functioning.

When iodides enter the epithelial cells of the thyroid gland follicles, under the influence of the enzyme iodide peroxidase, iodine is oxidized to form elemental iodine. The substance enters into a substitution reaction with the aromatic cycle of tyrosine, resulting in the formation of thyronines: a 3,5-iodine derivative (the hormone thyroxine – T4) and a 3-iodine derivative (the hormone triiodothyronine – T3). Thyronins form a complex with thyroglobulin protein, which is deposited in the colloid of the thyroid follicle and remains in this state for several days and weeks. With iodine deficiency, this process is disrupted. Iodine, which enters the body in physiological quantities, prevents the development of endemic goiter associated with a lack of this element in food; normalizes the size of the thyroid gland in adult patients; affects the ratio of T3 / T4,

After oral administration, iodine is almost completely absorbed in the small intestine. Within 2 hours after absorption, it is distributed in the intercellular space; accumulates in the thyroid gland, kidneys, stomach, mammary and salivary glands. The volume of distribution in a healthy person averages 23 liters (38% of body weight). The content of iodine in breast milk, saliva, gastric juice is 30 times higher than the concentration in blood plasma. The thyroid gland contains ¾ (10-20 mg) of all iodine in the body. About 80% of the ingested iodine is excreted from the body in the urine through the kidneys. With feces, 10-15% is excreted. When an equilibrium concentration is reached, the amount of excreted iodine is proportional to the daily intake with food.

Prevention of the development of iodine deficiency.

Prevention of recurrence of iodine-deficient goiter after surgical removal, as well as after the completion of complex treatment with thyroid hormone preparations.

Treatment of diffuse euthyroid goiter.

Hypersensitivity to iodine or one of the other components of the drug. Manifest hyperthyroidism. The use of potassium iodide in doses exceeding 150 mcg of iodine per day in latent hyperthyroidism. The use of potassium iodide in doses of 300 to 1000 μg of iodine per day for autonomous adenoma, focal and diffuse autonomous thyroid lesions, with the exception of preoperative iodine therapy for the purpose of blockade of the thyroid gland according to Plumer. Pulmonary tuberculosis. Hemorrhagic diathesis. Dermatitis herpetiformis Dühring (Dühring-Brock syndrome).