$14.00
Manufacturer: Ukraine
Antral is indicated for adults and children for the treatment of: acute and chronic hepatitis of various origins (viral, alcoholic, drug-induced, toxic); fatty degeneration and cirrhosis of the liver; inflammatory diseases of the gallbladder, spleen, pancreas; postcholecystectomy syndrome (after removal of the gallbladder). For the prevention of liver diseases due to the negative effects of toxins of various etiologies: alimentary toxins, drugs, chemotherapy, radiation therapy.
Description
Ingredients
active ingredient: 1 tablet contains antral in terms of dry matter 100 mg (0.1 g);
excipients : magnesium carbonate, potato starch, crospovidone, microcrystalline cellulose, povidone, polysorbate, colloidal silicon dioxide, calcium stearate, Opadry II 85 G18490 white, Opadry II 85 G25557 red.
Dosage form
Coated tablets.
Basic physical and chemical properties : round-shaped tablets with a biconvex surface, film-coated dark red.
Pharmacotherapeutic group
Hepatoprotective drugs. ATX code A05V A.
Pharmacodynamics
Antral belongs to the group of hepatoprotective drugs. It is effective in the treatment of acute and chronic hepatitis of various origins, cirrhosis of the liver, helps to reduce asthenovegetative disorders, improves appetite, sleep, and reduces dyspepsia. With a course application, the drug normalizes the content of bilirubin, γ-globulins, cholesterol in the blood, prothrombin index, transaminase activity (ALT and AST) and alkaline phosphatase. Antral has an inherent prolonged anti-inflammatory, analgesic effect. According to the results of preclinical studies, it was found that Antral in conditions of acute, subacute and chronic liver damage by various xenobiotics and their combinations helps to reduce the effects of hepatotoxins, activation of reparative processes in hepatocytes and practical normalization of indicators of the structural and functional state of the liver. The drug inhibits the processes of lipid peroxidation in the blood and tissues, maintains the activity of the body’s antioxidant systems, and stabilizes the structure of the liver and hepatocyte membranes. As a relatively harmless pharmacological agent, Antral does not affect the functions of organs and systems of the body, it has no cumulative properties, immunotoxic, locally irritating, allergenic, ulcerogenic, embryotoxic, teratogenic effects.
Pharmacokinetics
The maximum accumulation of the drug in the blood is observed after 3-4 hours, the half-life is 4-5 hours. Excreted with urine and feces.
Indications
Antral is indicated for adults and children for the treatment of: acute and chronic hepatitis of various origins (viral, alcoholic, drug-induced, toxic); fatty degeneration and cirrhosis of the liver; inflammatory diseases of the gallbladder, spleen, pancreas; postcholecystectomy syndrome (after removal of the gallbladder). For the prevention of liver diseases due to the negative effects of toxins of various etiologies: alimentary toxins, drugs, chemotherapy, radiation therapy.
Contraindications
Individual hypersensitivity to the components of the drug.
Violation of the excretory function of the kidneys.
Dosage and administration
Antral appoint inside after meals 3 times a day:
- adults and children over 10 years old – 200 mg per dose; with cirrhosis of the liver in the first week of treatment – 400 mg per dose, then within 2-3 weeks – 200 mg per dose;
- children 4-10 years old (including those with cirrhosis of the liver) – 100 mg per dose.
The duration of treatment depends on the nature and severity of the disease. The average course of treatment is 3-4 weeks. The course of treatment should be repeated after 3-4 weeks.
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