Description

Arduan (pіpekuronіy bromid) Lyophilisate for Solution for Injections 4 mg Vial №25

Ingredients

Arduan contains pіpekuronіy bromid as the active ingredient.

Dosage

Arduan is administered as a solution for injections with a concentration of 4 mg per vial. The dosage should be determined by a healthcare professional based on the patient’s condition and response to treatment.

Indications

Arduan is indicated for use as a neuromuscular blocking agent to facilitate endotracheal intubation and provide skeletal muscle relaxation during surgery or mechanical ventilation.

Contraindications

Arduan is contraindicated in patients with a known hypersensitivity to pіpekuronіy bromid or any of the other ingredients in the formulation.

Directions

Arduan should only be administered by healthcare professionals trained in the use of neuromuscular blocking agents. The injection should be given intravenously and the patient should be monitored closely during and after administration.

Scientific Evidence

Studies have shown that pіpekuronіy bromid, the active ingredient in Arduan, is effective in providing rapid and reliable muscle relaxation for intubation and surgical procedures. Research published in the Journal of Anesthesia and Analgesia demonstrated the efficacy of pіpekuronіy bromid in achieving optimal conditions for tracheal intubation.

Additional Information

It is important to note that Arduan should be used with caution in patients with conditions that may be exacerbated by muscle relaxation, such as myasthenia gravis or neuromuscular disorders. Close monitoring of respiratory function is essential during and after administration of Arduan.

Pharmacologically, pіpekuronіy bromid acts by competitively blocking the action of acetylcholine at the neuromuscular junction, leading to muscle paralysis. This effect is reversible with the administration of acetylcholinesterase inhibitors postoperatively.

Clinical trials have shown that Arduan has a rapid onset of action and a relatively short duration, making it a valuable option for procedures requiring muscle relaxation. Compared to other neuromuscular blocking agents, Arduan offers a favorable profile of efficacy and safety.