Argedin-Bosnalek (Silver Sulfadiazine) cream 1% 40 g. tube for external use

active ingredient : Silver Sulfadiazine;

composition per 1 dosage form unit: 1 g of cream contains silver sulfadiazine 10 mg;

excipients : white soft paraffin, propylene glycol, non-ionic emulsified wax, liquid paraffin, methyl parahydroxybenzoate (E 218), purified water.

Cream.

Basic physical and chemical properties: cream from white to slightly yellowish color, homogeneous consistency.

Antibacterial and chemotherapeutic drugs used in dermatology. Sulfonamides. ATX code D06B A01.

The mechanism of action of silver sulfadiazine is not fully understood. It is believed that it is a donor of silver ions, which, through a series of reactions, binds to the DNA of a bacterial cell. Sulfadiazine is released into the interstitial fluid. According to some data, it is possible that the entire complex binds to the bacterial cell wall.

Microbiological studies in vitro have shown that silver sulfadiazine has a wide spectrum of activity against such microorganisms:

Susceptible microorganisms: Pseudomonas maltophilia, Pseudomonas fluorescens, Proteus (providencia) rettgeri, Proteus vulgaris, Streptococcus pyogenes, Corynebacterium diphteriae, Herpes simplex, Herpesvirus hominis, Treponema pallidum, Microsporon audouinii, Trichophyton mentagrophytes.

Moderately susceptible microorganisms: Pseudomonas aeruginosa, Enterobacter cloacae, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Proteus morganii, Citrobacter sp. schoenleinii, Trichophyton tonsurans, Epidermophyton floccosum; Less sensitive microorganisms.

Less sensitive microorganisms: Klebsiella spp, Enterobacter species, Serratia spp, Shigella flexneri, Staphylococcus aureus, Enterococcus (group D Streptococcus), Clostridium perfringens, Candida albicans, Aspergillus fumigatus, Aspergillus flavus, Rhizopus nigricans.

Silver sulfadiazine penetrates into necrotic tissues and exudate, which is important, since systemic drugs are ineffective against bacterial flora in necrotic tissues.

Prevention of infection and treatment of infected burns and wounds; treatment of thermal and chemical burns.

• Hypersensitivity to sulfadiazine silver or other sulfonamides, silver or any other ingredient of the drug;
• genetic deficiency of glucose-6-phosphate dehydrogenase (when used on large surfaces, hemolysis may occur);
• purulent and burn wounds with massive exudation (not advisable);
• porphyria.