$19.00
Manufacturer: Poland
Silver sulfathiazole has a broad spectrum of antibacterial activity against mixed flora (gram-positive and gram-negative microorganisms), including Pseudomonas aeruginosa.
It inactivates and significantly reduces the infectious ability of herpes viruses outside the cell and the herpes zoster virus.
The drug effectively protects the wound from infection, forms a protective layer on the surface of the wound, maintains adequate moisture and promotes wound healing.
Description
Argosulfan cream 2%, 15 g
Ingredients
active ingredient: silver sulphathiazole;
1 g of the drug contains silver sulfathiazole 20 mg;
excipients: liquid paraffin, cetostearyl alcohol, white soft paraffin, sodium lauryl sulfate, glycerin, propyl parahydroxybenzoate (E 216), methyl parahydroxybenzoate (E 218), potassium dihydrogen phosphate, sodium hydrogen phosphate dodecahydrate, water for injection.
Dosage form
Cream.
Basic physical and chemical properties: white or white with a tinge from pink to light gray, homogeneous emulsion mass.
Pharmacotherapeutic group
Chemotherapeutic agents for local use. Sulfonamides. ATX code D06B A02.
Pharmacodynamics
The mechanism of the antimicrobial action of sulfathiazole, including inhibition of the growth and reproduction of microorganisms, is associated with competitive antagonism with para-aminobenzoic acid and suppression of dihydropteroate synthetase, which leads to a breakdown in the synthesis of dihydrofolic acid and, ultimately, its active metabolite, tetrahydrofolic acid, which is necessary for the synthesis of purines and pyrimidines microbial cell.
Silver sulfathiazole has a broad spectrum of antibacterial activity against mixed flora (gram-positive and gram-negative microorganisms), including Pseudomonas aeruginosa.
It inactivates and significantly reduces the infectious ability of herpes viruses outside the cell and the herpes zoster virus.
The drug effectively protects the wound from infection, forms a protective layer on the surface of the wound, maintains adequate moisture and promotes wound healing.
Pharmacokinetics
Silver sulfathiazole has the lowest degree of solubility among other silver salts of the sulfonamide group, as well as high stability. The low degree of solubility and high stability of silver sulfathiazole allows it to remain on the surface of the affected part of the skin and reduce absorption into the blood. Absorbed sulfathiazole is acetylated in the liver, after which it is excreted in the urine as inactive metabolites and partially unchanged. Absorption of sulfathiazole increases after application of the drug to large areas of the affected skin.
Indications
Argosulfan (silver sulphathiazole) is used topically to treat infections such as:
- skin burns of all degrees (including radiation);
- bedsores;
- trophic ulcers of the leg.
Contraindications
Hypersensitivity to sulfathiazole, other sulfonamides or excipients.
Argosulfan (silver sulphathiazole) should not be used:
- when breastfeeding;
- premature newborns and infants under two months of age due to the risk of subcutaneous jaundice (kernicterus);
- patients with congenital deficiency of glucose-6-phosphate dehydrogenase due to the risk of hemolytic anemia.
Dosage and administration
Application for burns.
Argosulfan (silver sulphathiazole) is intended for topical application both in an open way and with the use of occlusive dressings. Argosulfan® does not cause darkening of the skin and underwear.
After cleaning and surgical treatment of the wound, Argosulfan (silver sulphathiazole) cream is applied with a layer of 2-3 mm, observing sterility conditions. All affected areas of the skin should be covered with cream during the entire treatment period. If, for some reason, part of the wound is covered with a cream, an additional thin layer of the drug should always be applied. There is no need to apply an occlusive dressing to the wound, unless there is an indication for the use of a dressing. Apply the cream until the wound is completely healed or until the wound surface is prepared for skin grafting (surgical interventions).
Treatment of bedsores and trophic ulcers of the leg.
The drug is applied in a thin layer to the affected areas of the skin 2-3 times a day.
If the drug is applied to infected wounds, exudate may appear. In such cases, before applying the cream, it is necessary to wash the wound with a 0.1% aqueous solution of chlorhexidine, a 3% aqueous solution of boric acid, or another antiseptic. For adults, dosing control is not mandatory.
Patients with renal insufficiency
Due to the lack of clinical trials, caution should be exercised when using Argosulfan® in patients with renal insufficiency. In patients with severely impaired renal function, the concentration of sulfonamide in the blood serum should be monitored.
Patients with impaired liver function
Due to the lack of clinical trials, the drug should be used cautiously in patients with impaired liver function.
Application method
Argosulfan (silver sulphathiazole) is intended for use on the skin both in an open way and with the use of occlusive dressings.
Recent Reviews