Arifon Retard (indapamide) tablets coated 1.5 mg. №30

Arifon (indapamide) ret.tablets coated 1.5 mg. №30

$23.00

Manufacturer: France

Indapamide is a sulfonamide diuretic with an indole ring, pharmacologically related to thiazide diuretics and is prescribed for the treatment of arterial hypertension.

Indapamide acts at the level of the kidneys and blood vessels.

Category:

Description

Ingredients

active ingredient: indapamide

1 tablet contains 1.5 mg of indapamide;

excipients : lactose monohydrate, hypromellose (E 464), povidone, colloidal silicon dioxide (E 551), magnesium stearate (E 470 B), titanium dioxide (E 171), glycerin (E 422), macrogol 6000.

Dosage form

Film-coated tablets, prolonged release.

Basic physical and chemical properties: white, round-shaped tablets, film-coated.

Pharmacotherapeutic group

Diuretics with moderate diuretic activity, excluding thiazides. Sulfonamides, simple. Indapamide. ATX code C03B A11.

Pharmacodynamics

Mechanism of action

Indapamide is a sulfonamide diuretic with an indole ring, pharmacologically related to thiazide diuretics and is prescribed for the treatment of arterial hypertension.

Indapamide acts at the level of the kidneys and blood vessels.

Indapamide inhibits sodium reabsorption in the cortical segment of the kidneys. This increases the excretion of sodium and chlorides in the urine and, to a lesser extent, potassium and magnesium, thus increasing diuresis.

Pharmacodynamic effects

Phase II-III clinical studies using indapamide as monotherapy have shown that the antihypertensive effect of indapamide lasts for 24 hours. The diuretic effect was moderate. The antihypertensive effect of indapamide is associated with an improvement in arterial elasticity and a decrease in arteriole resistance and total peripheral vascular resistance.

Indapamide reduces left ventricular hypertrophy.

When the recommended dose is exceeded, the therapeutic effect of thiazides and thiazide-like diuretics does not increase, while the number of adverse events increases. If the treatment is not effective enough, it is not recommended to increase the dose.

As shown in studies of different duration (short, medium and long) in patients with arterial hypertension, indapamide:

  • does not affect lipid metabolism (triglycerides, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol),
  • does not affect the metabolism of carbohydrates, even in patients with diabetes and arterial hypertension.

Indapamide acts at the vascular level by:

  • a decrease in the contractility of vascular smooth muscles, which is associated with changes in the transmembrane exchange of ions (mainly calcium)
  • stimulation of the synthesis of prostaglandins PGE2 and prostacyclin PGI2 (vasodilator and inhibitor of platelet aggregation).

Indications

ARIFON® RETARD is indicated for essential hypertension in adults.

Contraindications

  • Hypersensitivity to the active substance, other sulfonamides or any excipients;
  • severe renal failure;
  • hepatic encephalopathy or severe liver dysfunction;
  • hypokalemia.

Dosage and administration

Mode of application

For oral use.

Dosage

1 tablet per day, preferably in the morning. The tablet should be swallowed whole, without chewing, with water.

The use of higher doses of the drug does not lead to an increase in the antihypertensive effect, but the diuretic effect increases.

Special patient groups

Renal failure

Patients with severe renal insufficiency (creatinine clearance <30 ml / min) use of the drug is contraindicated. Thiazide and thiazide-like diuretics are most effective if renal function is not impaired or if the impairment is minor.

Elderly age

In elderly patients, plasma creatinine should be at a level appropriate for age, body weight and sex. Elderly patients ARIFON® RETARD can be prescribed if the renal function is not impaired or if the impairment is minor.

Liver failure

In case of severe liver dysfunction, treatment is contraindicated.

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