Armadin (mexidol) Long tablets with prolonged release 500 mg. №40 vial

active ingredient: mexidol

1 tablet contains armadine (2-ethyl-6-methyl-3-hydroxypyridine succinate) 500 mg;

excipients: hydroxypropylcellulose, hypromellose (hydroxypropylmethylcellulose), colloidal silicon dioxide, succinic acid, magnesium stearate, talc, titanium dioxide (E 171).

Prolonged action tablets.

Basic physical and chemical properties: white or white with a creamy tint color with a biconvex smooth surface, film-coated tablets, possibly with a specific odor.

Drugs affecting the nervous system. ATX code N07X X.

Ethylmethylhydroxypyridine succinate belongs to heteroaromatic antioxidants. It has a wide range of pharmacological actions: it increases the body’s resistance to stress, has an anxiolytic effect that is not accompanied by drowsiness and a muscle relaxant effect, has nootropic properties, prevents and reduces memory disorders that occur due to aging and under the influence of various pathogenic factors, has an anticonvulsant effect; has antioxidant and antihypoxic properties; increases concentration and efficiency weakens the toxic effect of alcohol. The drug improves the metabolism of brain tissues and their blood supply, improves microcirculation and rheological properties of blood, reduces platelet aggregation.

The mechanism of action is due to its antioxidant and membrane-protective activity. It inhibits lipid peroxidation, increases the activity of superoxide oxidase, increases the lipid/protein ratio, and reduces membrane viscosity. Modulates the activity of membrane-bound enzymes (calcium independent phosphodiesterase, adenylate cyclase, acetylcholinesterase), receptor complexes (benzodiazepine, γ-aminobutyric acid (GABA), acetylcholine), which enhances their ability to bind to ligands, helps to preserve the structural and functional organization of biomembranes, transport neurotransmitters and improve synaptic transmission. Ethylmethylhydroxypyridine succinate increases dopamine content in the brain.

Armadin Long (mexidol) – a dosage form of prolonged action, provides a uniform release of the active substance within 10-12 hours and reduces the likelihood of side effects due to a sharp increase in its content in the blood plasma. The effect of the drug is manifested 3-4 hours after administration, when the concentration of the active substance in the blood plasma reaches a therapeutic level, a stable improvement in the condition is noted after 2-3 days when a stationary level of pharmacokinetic parameters is established. After discontinuation of the drug, its effect persists for another 3-5 days.

Absorption of the drug begins in the stomach and occurs in the small and large intestines. The rate of release and absorption of the active substance from Armadin Long (mexidol) tablets is practically independent of the area of ​​the gastrointestinal tract, pH and composition of the chyme.

Ethylmethylhydroxypyridine succinate in the human body is metabolized mainly in the liver by intensive conjugation with glucuronic acid and excreted in the urine both unchanged and in the form of glucuronconjugatives. Renal excretion rates of unchanged drug and its conjugated metabolites are characterized by significant individual variability.

• Consequences of acute cerebrovascular accident
• neurotic and neurosis-like states with symptoms of anxiety;
• cardiopsychoneurosis;
• mild cognitive disorders of various origins (with psychoorganic syndrome and asthenic disorders caused by acute and chronic cerebrovascular accidents, traumatic brain injuries, neuroinfections and intoxication, senile and atrophic processes);
• encephalopathy of various origins (dyscirculatory, dysmetabolic, post-traumatic, mixed);
• mild traumatic brain injury, consequences of traumatic brain injury;
• memory impairment and intellectual deficiency in the elderly;
• asthenic conditions, the influence of extreme (stress) factors;
• coronary heart disease (as part of complex therapy);
• withdrawal syndrome in alcoholism with a predominance of neurosis-like and vegetative-vascular disorders;
• conditions after intoxication with antipsychotropic drugs.

Acute liver or kidney failure, hypersensitivity to the components of the drug, childhood, pregnancy, lactation.

Armadin Long (mexidol) enhances the effect of benzodiazepine anxiolytics, antiparkinsonian drugs and carbamazepine, potentiates the effect of anticonvulsants, tranquilizers and analgesics. Armadin Long (mexidol) reduces the toxic effect of ethyl alcohol. Increases the hypotensive activity of ACE inhibitors (ACE), β-blockers. Increases antianginal activity of nitropreparations. Under the influence of the drug, the effect of sedatives, neuroleptics, antidepressants, hypnotics and anticonvulsants is enhanced, which allows to reduce their doses and reduce side effects.