Armadin (mexidol)coated tablets 125 mg. №30

active ingredient: mexidol (2-ethyl-6-methyl-3-hydroxypyridine succinate);

1 tablet contains mexidol (2-ethyl-6-methyl-3-hydroxypyridine succinate) 125 mg;

excipients: lactose monohydrate, potato starch; povidone, crospovidone; colloidal silicon dioxide magnesium stearate succinic acid; hydroxypropyl cellulose; talc titanium dioxide (E 171) hydroxypropyl methylcellulose.

Coated tablets.

Basic physical and chemical properties: white or white with a creamy tint color tablets with a biconvex smooth surface, film-coated.

Drugs affecting the nervous system. ATX code N07X X.

Ethylmethylhydroxypyridine succinate belongs to heteroaromatic antioxidants. It has a wide range of pharmacological actions: it increases the body’s resistance to stress, has an anxiolytic effect that is not accompanied by drowsiness and a muscle relaxant effect, has nootropic properties, prevents and reduces memory disorders that occur due to aging and under the influence of various pathogenic factors, has an anticonvulsant effect; exhibits antioxidant and antihypoxic properties; increases concentration and efficiency weakens the toxic effect of alcohol. The drug improves the metabolism of brain tissues and their blood supply, improves microcirculation and rheological properties of blood, reduces platelet aggregation.

The mechanism of action is due to its antioxidant and membrane-protective activity. It inhibits lipid peroxidation, increases the activity of superoxide oxidase, increases the lipid-protein ratio, and reduces membrane viscosity. Modulates the activity of membrane-bound enzymes (calcium independent phosphodiesterase, adenylate cyclase, acetylcholinesterase), receptor complexes (benzodiazepine, GABA, acetylcholine), which enhances their ability to bind to ligands, helps to preserve the structural and functional organization of biomembranes, transport neurotransmitters and improve synaptic transmission. ARMADIN® increases the content of dopamine in the brain. Under conditions of tissue ischemia, it enhances the compensatory activation of aerobic glycolysis and reduces the degree of inhibition of oxidative processes in the Krebs cycle.

The drug improves metabolism and blood supply to the brain, improves microcirculation and rheological properties of blood, reduces platelet aggregation. Stabilizes the membrane structures of blood cells (erythrocytes and platelets) during hemolysis. It has a hypolipidemic effect, reduces the content of total cholesterol and low density lipoproteins. The anti-stress effect is manifested in the normalization after stress, somatovegetative disorders, learning and memory disorders, restoration of sleep-wake cycles, reduction of dystrophic and morphological changes in various brain structures. ARMADIN® has a pronounced antitoxic effect in withdrawal symptoms. It eliminates neurological and neurotoxic manifestations of acute alcohol intoxication, restores behavioral disorders, vegetative functions, and is also able to relieve cognitive impairment caused by long-term use of ethanol and its withdrawal. Under the influence of ARMADIN, the effect of tranquilizers, neuroleptics, antidepressants, hypnotics and anticonvulsants is enhanced, which makes it possible to reduce their doses and reduce side effects. ARMADIN® improves the functional state of ischemic myocardium. In conditions of coronary insufficiency, it increases the collateral blood supply to the ischemic myocardium, helps to preserve the integrity of cardiomyocytes and support their functional activity. Effectively restores myocardial contractility in reversible cardiac dysfunction hypnotics and anticonvulsants, which allows to reduce their doses and reduce side effects. ARMADIN® improves the functional state of ischemic myocardium. In conditions of coronary insufficiency, it increases the collateral blood supply to the ischemic myocardium, helps to preserve the integrity of cardiomyocytes and support their functional activity. Effectively restores myocardial contractility in reversible cardiac dysfunction hypnotics and anticonvulsants, which allows to reduce their doses and reduce side effects. ARMADIN® improves the functional state of ischemic myocardium. In conditions of coronary insufficiency, it increases the collateral blood supply to the ischemic myocardium, helps to preserve the integrity of cardiomyocytes and support their functional activity. Effectively restores myocardial contractility in reversible cardiac dysfunction.