Artedja (chondroitin sulphate sodium) solution for injections 200 mg/2 ml. 2 ml. ampoules №10

Description

Ingredients

active ingredient: chondroitin sulphate sodium;

• 1 ampoule (2 ml) contains sodium chondroitin sulphate in terms of 100% substance 200 mg

excipients: benzyl alcohol, water for injection.

Dosage form

Injection.

Basic physical and chemical properties:

transparent colorless or slightly yellowish liquid with a specific odor.

Pharmaco-therapeutic group

Drugs that affect the musculoskeletal system. Chondroitin sulphate. ATX code M01A X25.

Pharmacological properties

Pharmacological. The main active ingredients of the drug are sodium salts of chondroitin sulfate A and C. Chondroitin sulfate is a high molecular weight  mucopolysaccharide. It is the main component of proteoglycans, which together with collagen fibers form the cartilage matrix.

The drug inhibits the process of degeneration and stimulates the regeneration of cartilaginous tissue, has a chondroprotective, anti-inflammatory, analgesic effect. Replaces chondroitin sulfate of articular cartilage, catabolization by a pathological process. Suppresses the activity of enzymes that cause degradation of articular cartilage: inhibits metalloproteinases, namely leukocyte elastase. Reduces the activity of hyaluronidase. Partially blocks the release of free oxygen radicals, helps to block chemotaxis, antigenic determinants. Stimulates the production of proteoglycans by chondrocytes. Affects phosphorus-calcium metabolism in cartilaginous tissue. Allows you to restore the mechanical and elastic integrity of the cartilage matrix.

The use of the drug helps to restore the joint capsule and cartilaginous surfaces of the joints, prevents compression of the connective tissue, acts as a lubricant for the articular surfaces, normalizes the production of joint fluid, improves joint mobility, helps reduce pain intensity, and improves quality of life.

The drug slows down the resorption of bone tissue and reduces the loss of calcium, accelerates the process of restoration of bone tissue.

Pharmacokinetics. After the introduction of chondroitin sulfate penetrates into the synovial fluid. The maximum concentration in the synovial fluid is reached 4-5 hours after the injection. It is excreted from the body within 24 hours. It is excreted mainly by the kidneys.

Indications

• Degenerative-dystrophic diseases of the joints and spine (primary arthrosis, intervertebral osteochondrosis, osteoarthritis),
• osteoporosis,
• periodontitis,
• fractures (to accelerate the formation of callus),
• treatment of the consequences of operations on the joints.

Contraindications

• Hypersensitivity to the components of the drug,
• tendency to bleed
• thrombophlebitis,
• kidney failure.

Dosage and administration

The drug is administered to adults intramuscularly, 1 ml every other day. In case of good tolerance, increase the dose to 2 ml starting from the fourth injection. The course of treatment is 25-35 injections. Repeated courses – in 6 months.

Package

2 ml in ampoules. 10 ampoules in a pack or 5 ampoules in a blister, 2 blisters in a pack.