Artiflex (glucosamine) powder 1.5g/4g. sackets №20

active ingredient: glucosamine;

1 package contains glucosamine sodium chloride sulfate (equivalent to 1.5 g of glucosamine sulfate and 0.384 g of sodium chloride) – 1.884 g;

excipients: sorbitol (E 420), citric acid, aspartame (E 951), polyethylene glycol 4000.

Powder for oral solution.

Basic physical and chemical properties: crystalline powder from white to white with a yellowish tint.

Other non-steroidal anti-inflammatory and antirheumatic drugs.

ATX code M01A X05.

The active ingredient is a salt of the amino monosaccharide glucosamine sulfate, which is present in the human body and is used together with sulfates for the biosynthesis of hyaluronic acid in synovial fluid and glycosaminoglycans of the main substance of articular cartilage.

The mechanism of action of glucosamine sulfate is the stimulation of the synthesis of glycosaminoglycans and, accordingly, articular proteoglycans. In addition, glucosamine exhibits anti-inflammatory properties, slows down the destruction of articular cartilage mainly due to its metabolic activities, the ability to suppress the activity of interleukin 1 (IL-1), which, on the one hand, contributes to the effect on the symptoms of osteoarthritis, and on the other hand, delays structural joint disorders, as evidenced by data from long-term clinical studies.

The effectiveness of glucosamine sulfate against osteoarthritis is evident already after 2-3 weeks from the start of treatment.

There are data from clinical trials of daily continuous treatment for 3 years, showing a progressive increase in the effectiveness of glucosamine sulfate, taking into account the symptoms and slowing down of structural damage to the joints, confirmed by x-ray.

No significant effect of glucosamine sulfate on the cardiovascular, respiratory, autonomic or central nervous system was found.

90% of the dose of glucosamine sulfate is quickly and completely absorbed from the gastrointestinal tract, passes through biological barriers and penetrates tissues, mainly articular cartilage. Bioavailability – 26%. T ½ – 68 hours.

For relief of symptoms in mild to moderate osteoarthritis of the knee.

Hypersensitivity to the components of the drug. Violation of the functions of the liver and kidneys in the stage of decompensation, a tendency to bleeding. Allergy to shellfish (active ingredient derived from shellfish).