Artiflex Ultra (chondroitin sulfate) capsules №120

active ingredients: glucosamine, chondroitin sulfate, ibuprofen;

1 capsule contains glucosamine sulfate sodium chloride in terms of glucosamine sulfate 250 mg chondroitin sulfate sodium 200 mg, ibuprofen 100 mg;

excipients: corn starch, crospovidone, sodium starch (type A), stearic acid, microcrystalline cellulose, magnesium stearate, povidone, silicon dioxide colloidal capsule shell contains gelatin, titanium dioxide (E 171).

Capsules.

Basic physical and chemical properties: white hard gelatin capsules. The contents of the capsules are a mixture containing granules and powder from white to almost white. The presence of agglomerates of particles is allowed.

It is allowed to apply the trademark of the enterprise – ZT on the capsule.

Combined anti-inflammatory (anti-inflammatory) drugs. Code ATX M01B.

This drug stimulates the regeneration of cartilage tissue. It has an anti-inflammatory effect at the cellular level, stimulates the synthesis of both endogenous proteoglycans and endogenous hyaluronic acid, reduces the catabolic activity of chondrocytes by inhibiting certain enzymes that destroy cartilage, such as collagenase, elastase, proteoglycinase, phospholipase-A2, N-acetylglycosaminidase, etc. and also inhibits the formation of other substances that can damage cartilage (in vitro), such as superoxide radicals; activity of lysosomal enzymes.

Chondroitin and glucosamine are effective in patients with osteoarthritis.

Chondroitin is one of the main elements of cartilage. It reduces the activity of the inflammatory process in the early stages and thus slows down the degeneration of cartilage tissue. Helps reduce pain, improves joint function and reduces the need for NSAIDs (NSAIDs) in osteoarthritis of the knee and hip joints.

Glucosamine is physiologically present in the human body and has chondroprotective properties. In vitro and in vivo studies have shown that glucosamine hydrochloride stimulates the synthesis of physiological glycosaminoglycans and proteoglycans by chondrocytes and the synthesis of hyaluronic acid by synoviocytes.

Ibuprofen has antipyretic, analgesic and anti-inflammatory effects. The mechanism of action is associated with non-selective blocking of cyclooxygenase (COX) types 1 and 2 (the main enzyme of arachidonic acid metabolism), which leads to a decrease in the synthesis of prostaglandins, a decrease in their concentration in the cerebrospinal fluid and a weakening of the excitation of the thermoregulation center. Reduces morning stiffness, increases range of motion in the joints and spine.

The combined use of glucosamine and ibuprofen leads to an increase in the level of analgesic activity of the latter.