$7.00
Manufacturer: Ukraine
Ascorbic acid 10% is used for hypovitaminosis C; scurvy; bleeding (uterine, pulmonary, nasal, hepatic); hemorrhagic diathesis; bleeding as a syndrome of radiation sickness; various intoxications and infectious diseases; nephropathy of pregnant women; addisonian crisis; overdose of anticoagulants; bone fractures and flaccid wounds; various dystrophies; increased brain tension and hard physical labor.
Description
Ingredients
active substance ascorbic acid;
1 ml of solution contains ascorbic acid 100 mg;
excipients: sodium bicarbonate, anhydrous sodium sulfite (E 221), disodium edetate, water for injection.
Dosage form
Injection.
Basic physical and chemical properties: transparent colorless or slightly colored liquid.
Pharmacotherapeutic group
Simple preparations of ascorbic acid. Ascorbic acid (vitamin C). ATX code A11G A01.
Pharmacodynamics
Ascorbic acid (vitamin C) is a water-soluble vitamin that contributes to the optimal course of tissue metabolism. Actively participates in redox reactions, forming a hydrogen proton transfer system with dehydroascorbic acid, exhibits antioxidant properties, due to which it ensures the stability of cell membranes. Participates in the synthesis of the main substance of the connective tissue of the vascular wall, thus preventing the development of hemorrhagic diathesis. It is not synthesized in the human body. With insufficient intake of ascorbic acid with food, bleeding from the gums and mucous membranes develops. Participates in glucose metabolism, cholesterol catabolism, synthesis of steroid hormones. During stress reactions, the content of ascorbic acid in the body and in the tissues of the adrenal glands in particular is significantly reduced, which confirms the participation of ascorbic acid in adaptation reactions. It is able to exert anti-anemic action due to the influence on iron metabolism. Restores ferric iron to ferrous iron, which is transported with the blood stream.
Indications
Hypovitaminosis C; scurvy; bleeding (uterine, pulmonary, nasal, hepatic); hemorrhagic diathesis; bleeding as a syndrome of radiation sickness; various intoxications and infectious diseases; nephropathy of pregnant women; addisonian crisis; overdose of anticoagulants; bone fractures and flaccid wounds; various dystrophies; increased brain tension and hard physical labor.
Contraindications
Hypersensitivity to the active substance or to other components of Ascorbic acid 10%; diabetes; increased blood clotting; tendency to thrombosis; thrombophlebitis; urolithiasis (including hyperoxaluria); kidney failure; progressive malignant diseases; hemochromatosis; thalassemia; polycythemia; leukemia; sideroblastic anemia; sickle cell anemia; deficiency of glucose-6-phosphate dehydrogenase.
Dosage and administration
Ascorbic acid 10% is prescribed intravenously by stream or drip and intramuscularly.
Intravenous bolus injection for 1 – 3 minutes. For intravenous drip, a single dose of the drug is dissolved in 50-100 ml of 0.9% sodium chloride solution and administered by slow intravenous infusion at a rate of 30-40 drops per minute.
Intramuscularly injected deep into the muscle.
Doses are set individually, taking into account the nature and severity of the disease.
Adults and children from 12 years old.
Ascorbic acid 10% is prescribed at a dose of 50 – 150 mg (0.5 – 1.5 ml of a 10% solution) per day. The maximum single dose is 200 mg (2 ml of a 10% solution), daily – 1 g (10 ml of a 10% solution). In acute poisoning, the maximum dose is up to 500 mg (50 ml of a 10% solution) per day.
Children up to 12 years old.
The drug is prescribed intravenously at a daily dose of 5-7 mg/kg of body weight in the form of a 5% solution (0.5-2 ml). Usually for children, daily doses are: under the age of 6 months – 30 mg, 6 – 12 months – 35 mg, 1 – 3 years – 40 mg, 4 – 10 years – 45 mg, 11 – 12 years – 50 mg.
The maximum daily dose is 100 mg.
Special groups of patients.
For patients with recurrent kidney stones, the daily dose of ascorbic acid should not exceed 100-200 mg.
For patients with severe or terminal renal failure (patients on dialysis), the daily dose of ascorbic acid should not exceed 50-100 mg.
For patients with deficiency of glucose-6-phosphate dehydrogenase, the daily dose of ascorbic acid should not exceed 100-500 mg.
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