Ascoril (salbutamol sulfate equivalent) tablets №20

Description

Ingredients

active substances: 1 tablet contains:

• salbutamol sulfate is equivalent to salbutamol 2 mg,
• bromhexine hydrochloride 8 mg,
• guaifenesin 100 mg;

auxiliary substances : calcium hydrogen phosphate, corn starch, methyl parahydroxybenzoate (E 218), propyl parahydroxybenzoate (E 216), talc, colloidal anhydrous silicon dioxide, magnesium stearate.

Medicinal form

Tablets.

The main physical and chemical properties:

white, round, flat tablets with bevelled edges, with a break line on one side.

Pharmacotherapeutic group

Combined remedies used for coughs and colds. Expectorants. Combinations.

ATX code R05C A10.

Pharmacological properties

Pharmacodynamics.

Salbutamol is a direct sympathomimetic, a selective β2-adrenoceptor agonist. The main action of b-adrenomimetics consists in the ability to stimulate adenylate cyclase, an enzyme that catalyzes the formation of cyclic adenosine monophosphate (cAMP) from adenosine triphosphate (ATP). An increase in the amount of cAMP causes the relaxation of bronchial smooth muscles and inhibits the release of mediators of immediate hypersensitivity from cells, especially mast cells. Salbutamol relaxes the smooth muscles of the bronchi, uterus, vascular bed of skeletal muscles. Salbutamol exerts a stronger and longer-lasting effect on β2-adrenoceptors than isoproterenol. Salbutamol can also improve mucociliary transport mechanisms.

Bromhexine has an expectorant and mucolytic effect. Bromhexine is a derivative of benzylamine and vazicin. Increases the volume of sputum, reduces its viscosity and promotes its evacuation from the bronchi; stimulates hydrolytic depolymerization of mucoprotein fibers and stimulates the activity of the ciliated epithelium. It is known that bromhexine releases lysosomal enzymes by bronchial glands.

Other pharmacological effects of bromhexine are also known: increased secretion of exocrine glands (for example, lacrimation) and increased production of pulmonary surfactant. Simultaneous use of bromhexine with oxytetracycline, erythromycin, ampicillin, amoxicillin leads to an increase in their concentration in sputum.

It is believed that the bromhexine metabolite, ambroxol (NA-872), may contribute to increased secretion of exocrine glands during the use of bromhexine.

Guaifenesin. The action of guaifenesin consists in stimulating the receptors of the mucous membrane of the stomach and reflex stimulation of the secretion of the glands of the respiratory tract. As a result, the volume increases and the viscosity of the bronchial secretion decreases.

Indication

Symptomatic treatment of productive cough in various respiratory diseases accompanied by bronchospasm.

Contraindications

• Hypersensitivity to salbutamol, other sympathomimetics, bromhexine, guaifenesin or any of the other components of Ascoril (salbutamol),
• coronary insufficiency,
• arrhythmia,
• other serious cardiovascular diseases,
• hyperthyroidism,
• severe liver function disorders,
• stomach and duodenal ulcer or peptic ulcer disease in the anamnesis,
• porphyria

Dosage and administration

• Adults and children over 12 years of age use 1 tablet 3 times a day.
• Children aged 6 to 12 years: ½ to 1 tablet 3 times a day.

The duration of treatment with Ascoril (salbutamol) is determined individually.