$24.00
Manufacturer: Estonia
Asibrox (acetylcysteine) is used for the treatment of acute and chronic diseases of the bronchopulmonary system, accompanied by increased sputum production.
Description
Ingredients
active ingredient: acetylcysteine;
1 effervescent tablet contains acetylcysteine 200 mg or 600 mg;
excipients: ascorbic acid, anhydrous sodium carbonate, sodium bicarbonate, citric acid, sorbitol (E 420), macrogol 6000, sodium, sodium saccharin, lemon flavor.
Dosage form
The tablets are effervescent.
Basic physical and chemical properties: flat-cylindrical tablets of white color with a line, slight marbling is allowed, with a characteristic odor.
Pharmacotherapeutic group
mucolytic agents. ATX code R05C B01.
Pharmacodynamics
N-acetylcysteine has a mucolytic effect. The presence of sulfhydryl groups in the structure of acetylcysteine contributes to the rupture of disulfide bonds of sputum acid mucopolysaccharides, which leads to depolarization of mucoproteins and a decrease in mucus viscosity. Remains active in the presence of purulent sputum.
Moreover, acetylcysteine has a direct antioxidant effect, due to the presence of a free thiol (-SH) nucleophilic group, which easily interacts with electrophilic groups of oxidizing radicals. In particular, current data are of interest that acetylcysteine protects α-antitrypsin, a protein that inhibits elastase, from destruction by perchloric acid, a pronounced oxidizing agent, produced by the myeloperoxidase protein of activated phagocytes.
Therefore, acetylcysteine can be used to treat acute and chronic diseases of the respiratory system, accompanied by a thick and viscous secretion.
Due to its molecular structure, acetylcysteine can easily penetrate cell membranes. Inside the cell, acetylcysteine is deacetylated to L-cysteine, an amino acid that is needed for the synthesis of glutathione.
Glutathione is a highly reactive tripeptide, which is a pronounced factor of intracellular protection not only from oxidative toxins of both exogenous and endogenous origin, but also from a number of cytotoxic substances.
Indications
- Treatment of acute and chronic diseases of the bronchopulmonary system, accompanied by increased sputum production.
- Paracetamol overdose.
Contraindications
- Hypersensitivity to acetylcysteine, other substances with a similar chemical structure or other excipients of the drug.
- Peptic ulcer of the stomach and duodenum in the acute stage, hemoptysis, pulmonary bleeding.
- Age up to 2 years.
Dosage and administration
Asibrox (acetylcysteine) is intended for oral use. Effervescent tablets should be dissolved in 1/3 glass of water and drunk as soon as possible. It is recommended to take after meals. To enhance the mucolytic effect of acetylcysteine, additional fluid intake is recommended.
Effervescent tablets 200 mg
Adults and children over 12 years old.
The drug is used at a dose of 400-600 mg per day, divided into 1-3 doses.
Children 6-12 years old.
The drug is used at a dose of 400-600 mg per day, divided into 1-3 doses.
Children 2-6 years old.
The drug is used at a dose of 200-400 mg per day, divided into 1-3 doses.
Effervescent tablets 600 mg
Adults and children over 12 years old.
Asibrox (acetylcysteine) is used at a dose of 600 mg 1 time per day.
The doctor determines the duration of the course of treatment individually, depending on the nature of the disease (acute or chronic).
Paracetamol overdose.
In the first 10 hours after taking a toxic substance, acetylcysteine should be applied as soon as possible at the rate of 140 mg / kg, then at the rate of 70 mg / kg every 4:00 for 1-3 days.
Asibrox (acetylcysteine) should be taken without delay, immediately after preparing the solution.
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