Description
Atocor (Atorvastatin) Coated Tablets 10 mg. №30
Composition
Each tablet contains 10 mg of atorvastatin.
Mechanism of Action
Atocor (atorvastatin) works by inhibiting HMG-CoA reductase, an enzyme in the liver that is crucial for cholesterol production. By blocking this enzyme, atorvastatin reduces the synthesis of cholesterol, leading to decreased levels of LDL cholesterol and triglycerides in the blood.
Pharmacological Properties
Atorvastatin is a selective, competitive inhibitor of HMG-CoA reductase. It lowers LDL cholesterol levels by upregulating LDL receptors and increasing the clearance of LDL particles. Additionally, atorvastatin has been shown to have anti-inflammatory and antioxidant properties that may contribute to its cardiovascular benefits.
Indications for Use
Atocor (atorvastatin) is indicated for the treatment of hypercholesterolemia to reduce elevated total cholesterol, LDL cholesterol, and apolipoprotein B levels. It is also prescribed for the prevention of cardiovascular events in patients with or at risk of coronary heart disease.
Contraindications
Avoid taking Atocor if you are pregnant, breastfeeding, or have active liver disease. Consult your healthcare provider before initiating treatment with atorvastatin, especially if you have a history of muscle disorders or are taking other medications that may interact with statins.
Side Effects
- Common side effects may include headache, muscle pain, nausea, and gastrointestinal disturbances.
- Rare but serious side effects can include myopathy, rhabdomyolysis, and liver dysfunction. Contact your doctor immediately if you experience unexplained muscle pain, weakness, or dark urine.
Usage Instructions
The typical dosage of Atocor ranges from 10 mg to 80 mg taken once daily, depending on the individual’s lipid profile and cardiovascular risk. It can be administered with or without food. Adherence to the prescribed dose is crucial for optimal therapeutic outcomes.
Benefits Compared to Analogues
Atorvastatin has demonstrated superior efficacy in reducing LDL cholesterol levels compared to other statins. Its ability to stabilize atherosclerotic plaques and improve endothelial function sets it apart as a cornerstone therapy for cardiovascular risk reduction.
Suitable Patient Groups
Atocor is suitable for adult patients with hypercholesterolemia, including those with familial hypercholesterolemia. It is generally well-tolerated across various age groups, including the elderly, but caution is advised in patients with renal impairment or a history of statin intolerance.
Storage and Shelf Life
Store Atocor tablets in a cool, dry place away from direct sunlight. Ensure the packaging is tightly closed to protect from moisture. Check the expiration date on the blister pack and do not use the medication if past the indicated shelf life.
Packaging Description
Each blister pack of Atocor contains 30 coated tablets of 10 mg strength. The packaging is designed to maintain the stability and integrity of the tablets, protecting them from environmental factors that could affect their quality.
Clinical Evidence and Proven Effectiveness
Studies have shown that atorvastatin significantly reduces the incidence of major cardiovascular events, including heart attacks and strokes. Notably, research published in the New England Journal of Medicine has highlighted the pivotal role of atorvastatin in primary and secondary prevention of cardiovascular diseases.
Atorvastatin’s efficacy in improving lipid profiles and its favorable safety profile have been consistently demonstrated in large-scale clinical trials. The evidence supports the use of Atocor as a cornerstone therapy for managing dyslipidemia and reducing cardiovascular risk.
