Description
Atorvastatin (Atorvastatin) Coated Tablets 10 mg. №90
Composition
Active ingredient: Atorvastatin calcium.
Other ingredients: Calcium carbonate, microcrystalline cellulose, lactose monohydrate, croscarmellose sodium, polysorbate 80, magnesium stearate, Opadry White Y-1-7000.
Mechanism of Action
Pharmacological Properties: Atorvastatin inhibits HMG-CoA reductase, reducing cholesterol synthesis and lowering LDL cholesterol levels. This mechanism helps prevent atherosclerosis and decreases the risk of cardiovascular events.
Indications for Use
Indications: Atorvastatin is prescribed as an adjunct to diet for managing elevated total cholesterol, LDL cholesterol, apolipoprotein B, and triglycerides in patients with primary hypercholesterolemia.
Contraindications
Contraindications:
- You are allergic to atorvastatin or any other components in the formulation.
- You have active liver disease or unexplained persistent elevations in liver function tests.
- You are pregnant, planning to become pregnant, or breastfeeding.
Side Effects
Common side effects may include muscle pain, weakness, and gastrointestinal symptoms. Contact your healthcare provider if you experience any adverse reactions.
Usage Instructions
Dosage: The typical starting dose is 10 mg once daily. Dosage adjustments may be made based on individual patient requirements and medical status.
Administration: Swallow the tablet whole with a glass of water. It can be taken with or without food.
Benefits Compared to Analogues
Atorvastatin has demonstrated superior efficacy in reducing LDL cholesterol levels compared to other statins. Its proven cardiovascular benefits make it a preferred choice for managing hypercholesterolemia.
Suitable Patient Groups
Atorvastatin is suitable for adult patients, including the elderly, with primary hypercholesterolemia. It is not recommended for use in pregnant or breastfeeding individuals.
Storage and Shelf Life
Storage: Keep atorvastatin at controlled room temperature, protected from moisture and heat. Ensure it is stored out of the reach of children.
Shelf Life: Check the expiration date on the packaging and do not use the product beyond that date.
Packaging Description
The product is available in blister packs containing 90 coated tablets of 10 mg each. The packaging is designed to maintain product integrity and ensure dosage accuracy.
Clinical Evidence and Proven Effectiveness
Atorvastatin has been extensively studied in clinical trials, demonstrating its efficacy in reducing LDL cholesterol and lowering the risk of cardiovascular events. Notably, a study published in the New England Journal of Medicine highlighted the significant cardiovascular benefits of atorvastatin therapy.
Clinical studies have shown that atorvastatin effectively reduces the incidence of heart attacks, strokes, and revascularization procedures in high-risk patients. A meta-analysis published in the Journal of the American College of Cardiology further supported the cardiovascular advantages of atorvastatin treatment.
