Description

Atrogrel (Clopidogrel) Coated Tablets 75 mg. №60

Composition

Active ingredient: Clopidogrel bisulfate 75 mg. Inactive ingredients: microcrystalline cellulose, hydrogenated castor oil, hydroxypropyl cellulose, mannitol, ferric oxide, and more.

Mechanism of Action

Clopidogrel, the active ingredient in Atrogrel tablets, is a platelet aggregation inhibitor that works by irreversibly binding to the P2Y12 receptor on platelets, preventing platelet activation and aggregation. This mechanism of action makes clopidogrel an essential medication in preventing thrombotic events in patients at risk.

Pharmacological Properties

Clopidogrel is a thienopyridine class antiplatelet agent that inhibits the binding of adenosine diphosphate (ADP) to its platelet receptor, thereby inhibiting platelet activation and aggregation.

Indications for Use

Atrogrel (Clopidogrel) coated tablets are indicated for the prevention of blood clots in patients with a history of recent heart attack, stroke, or peripheral arterial disease.

Contraindications

Do not use Atrogrel (Clopidogrel) coated tablets if you have an active bleeding disorder or a history of hypersensitivity to clopidogrel.

Side Effects

Common side effects of Atrogrel tablets may include bruising, nosebleeds, and gastrointestinal upset.

Usage Instructions

Directions: Swallow the tablets whole with water. It can be taken with or without food. Do not crush or chew the tablets.

Dosage: The recommended dosage is 75 mg once daily. Consult a healthcare professional for personalized dosing instructions.

Benefits Compared to Analogues

Atrogrel tablets offer a potent antiplatelet effect with a lower risk of adverse events compared to some other antiplatelet medications.

Suitable Patient Groups

Atrogrel tablets are suitable for adult patients, including the elderly, with a history of cardiovascular events or peripheral arterial disease.

Storage and Shelf Life

• Storage: Store at room temperature away from moisture and heat.
• Shelf Life: Check the packaging for the expiration date.

Packaging Description

Each pack of Atrogrel tablets contains 60 coated tablets of 75 mg strength.

Clinical Evidence and Proven Effectiveness

Several clinical trials have demonstrated the efficacy of clopidogrel in reducing the risk of cardiovascular events in patients with atherosclerosis. The CAPRIE study showed that clopidogrel was more effective than aspirin in reducing the combined risk of myocardial infarction, stroke, or vascular death in high-risk patients.