$8.00
Manufacturer: Ukraine
Atropin (atropine sulfate) is used as a symptomatic remedy for peptic ulcer of the stomach and duodenum, pylorospasm, acute pancreatitis, cholelithiasis, cholecystitis, spasms of the intestines, urinary tract, bronchial asthma, bradycardia due to increased vagal tone, to reduce the secretion of the salivary, gastric, bronchial, and sometimes sweat glands , for X-ray examination of the digestive tract (decrease in tone and motor activity of organs).
Description
Ingredients
active ingredient: atropine;
1 ml of atropine sulfate 1 mg;
excipients: hydrochloric acid, water for injection.
Dosage form
Injection.
Basic physical and chemical properties: transparent colorless liquid.
Pharmacotherapeutic group
Drugs used for the treatment of functional gastrointestinal disorders. Belladonna alkaloids, tertiary amines. Atropine. ATX code A03B A01.
Pharmacodynamics
Atropine is an alkaloid contained in plants of the nightshade family, a blocker of M-cholinergic receptors, equally associated with M1, M2, and M3 subtypes of muscarinic receptors. It affects both central and peripheral M-cholinergic receptors. It also acts (although much weaker) on H-cholinergic receptors. Interferes with the stimulating action of acetylcholine; reduces the secretion of the salivary, gastric, bronchial, lacrimal and sweat glands. Reduces the tone of the muscles of internal organs (bronchus, gastrointestinal tract, pancreas, bile ducts and gallbladder, urethra, bladder) causes tachycardia, improves atrioventricular conduction. Reduces the motility of the gastrointestinal tract, has virtually no effect on the secretion of bile and pancreas. Dilates pupils, impedes the outflow of intraocular fluid, increases intraocular pressure, causes paralysis of accommodation. In average therapeutic doses, it affects the central nervous system (CNS) and causes a delayed, but long-lasting sedative effect, excites breathing.
Indications
As a symptomatic remedy for peptic ulcer of the stomach and duodenum, pylorospasm, acute pancreatitis, cholelithiasis, cholecystitis, spasms of the intestines, urinary tract, bronchial asthma, bradycardia due to increased vagal tone, to reduce the secretion of the salivary, gastric, bronchial, and sometimes sweat glands , for X-ray examination of the digestive tract (decrease in tone and motor activity of organs).
The drug is indicated for use before anesthesia and surgery and during surgery as an agent that prevents broncho and laryngospasms, reduces glandular secretion, reflex reactions and side effects due to excitation of the vagus nerve. As a specific antidote for poisoning with cholinomimetic compounds and anticholinesterase (including organophosphorus) substances.
Contraindications
Hypersensitivity to the components of the drug. Diseases of the cardiovascular system, in which an increase in heart rate may be undesirable: atrial fibrillation, tachycardia, chronic heart failure, coronary heart disease (CHD), mitral stenosis, severe arterial hypertension. Acute bleeding. thyrotoxicosis. hyperthermia syndrome. Diseases of the gastrointestinal tract, accompanied by obstruction (achalasia of the esophagus, pyloric stenosis, intestinal atony and toxic megacolon). Glaucoma. Liver and kidney failure. Myasthenia gravis. Urinary retention or a predisposition to it (for example, due to disease of the prostate or urethra). Brain damage.
Dosage and administration
Atropine sulfate is administered subcutaneously, intramuscularly, intravenously.
With induction anesthesia in order to reduce the risk of vagus suppression of the heart rate and reduce the secretion of the salivary and bronchial glands – 0.3-0.6 mg under the skin or 30-60 minutes before anesthesia in combination with morphine (10 mg of morphine sulfate) – 1:00 before anesthesia. In case of poisoning with anticholinesterase drugs, atropine sulfate is administered intramuscularly at a dose of 2 mg every 20-30 minutes until redness and dryness of the skin, dilated pupils and the appearance of tachycardia, and normalization of breathing occur. In moderate and severe poisoning, atropine can be administered for two days (until signs of “reatropinization” appear).
For children, the highest single dose, depending on age, is:
- up to 6 months – 0.02 mg;
- from 6 months to 1 year – 0.05 mg;
- from 1 to 2 years – 0.2 mg;
- from 3 to 4 years – 0.25 mg;
- from 5 to 6 years – 0.3 mg;
- from 7 to 9 years – 0.4 mg;
- from 10 to 14 years – 0.5 mg.
Higher doses for adults subcutaneously: single – 1 mg, daily – 3 mg.
With caution, prescribe atropine sulfate to elderly patients.
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