Description
Avastin (Bevacizumab) Concentrate for Infusions 400 mg/16 ml – №1 Vial
Ingredients
Active Ingredient: Bevacizumab
Inactive ingredients may include sodium chloride, polysorbate 20, and water for injection.
Mechanism of Action
Avastin works by inhibiting the formation of new blood vessels, a process called angiogenesis, that tumors need to grow and spread. By blocking this process, Avastin helps to slow or stop tumor growth.
Pharmacological Properties
Bevacizumab is a monoclonal antibody that specifically binds to vascular endothelial growth factor (VEGF) and inhibits its interaction with receptors on the surface of endothelial cells. This action suppresses angiogenesis, reducing blood supply to tumors and hindering their growth.
Indications for Use
Avastin is indicated for the treatment of various cancers, including colorectal, lung, breast, and kidney cancer. It is used in combination with other anticancer therapies.
Contraindications
Avastin is contraindicated in patients with a history of severe allergic reactions to bevacizumab or any of the excipients in the formulation. It should not be used in patients with uncontrolled hypertension, recent major surgery, or active bleeding.
Side Effects
Common side effects of Avastin may include hypertension, proteinuria, bleeding, gastrointestinal perforation, wound healing complications, and neutropenia. Patients should be monitored for signs of these adverse reactions during treatment.
Usage Instructions
The recommended dose of Avastin is 5 mg/kg of body weight administered as an intravenous infusion every 2 weeks. The infusion should be administered by a healthcare professional experienced in the use of anticancer therapies.
Benefits Compared to Analogues
Avastin has demonstrated superior efficacy in clinical trials compared to some traditional cancer treatments. Its targeted mechanism of action offers a more precise approach to inhibiting tumor growth, potentially leading to better outcomes for patients.
Suitable Patient Groups
Avastin is suitable for adult patients with various types of cancer. It is not recommended for use in children, pregnant women, or elderly patients with compromised renal function unless the potential benefits outweigh the risks.
Storage and Shelf Life
Store Avastin in the refrigerator at 2°C to 8°C. Do not freeze. Protect from light. Once removed from the refrigerator, the product should be used within 8 hours if stored at 2°C to 8°C.
Packaging Description
Avastin is supplied in vials containing 400 mg of bevacizumab in 16 ml of solution for intravenous infusion. Each vial is for single use only and should be visually inspected for particulate matter or discoloration before administration.
Clinical Evidence and Proven Effectiveness
Several clinical trials have demonstrated the efficacy of Avastin in the treatment of various cancers. For example, a study published in the Journal of Clinical Oncology showed that Avastin, when combined with chemotherapy, significantly improved progression-free survival in patients with metastatic colorectal cancer.
