Description

Avelox (moxifloxacin) solution for infusions 400 mg. 250 ml. №1

Ingredients

Active ingredient: Moxifloxacin
Other ingredients: Sodium chloride, hydrochloric acid, sodium hydroxide, and water for injections.

Dosage

Recommended dosage: The usual dose is 400 mg once daily. The duration of therapy depends on the type and severity of the infection.

Indications

Indicated for: Treatment of infections caused by susceptible bacteria including respiratory tract infections, skin and soft tissue infections, and intra-abdominal infections.

Contraindications

Do not use Avelox if: You have a history of hypersensitivity to moxifloxacin or other quinolones, or if you have a history of tendon disorders related to fluoroquinolone use.

Directions

Administration: Avelox should be administered by intravenous infusion over a period of 60 minutes. It should not be mixed with other medications in the same infusion.

Scientific Evidence

Pharmacological effects: Moxifloxacin, a fluoroquinolone antibiotic, exerts its bactericidal action by inhibiting DNA gyrase and topoisomerase IV enzymes, essential for bacterial DNA replication and repair.

Clinical trials: Clinical studies have demonstrated the efficacy of Avelox in treating various bacterial infections with a favorable safety profile. In a study by Patel et al., Avelox showed high efficacy in treating community-acquired pneumonia.

Additional Information

• Warnings: Avelox may cause serious side effects including tendon rupture, peripheral neuropathy, and central nervous system effects. It should be used with caution in patients with known risk factors for these conditions.
• Storage: Store the solution for infusion at controlled room temperature between 20°C to 25°C (68°F to 77°F).