Description
Axsef (Cefuroxime) Powder Solution for Injections 750 mg Vial + Solvent Ampoules 6 ml
Ingredients
Active ingredient: Cefuroxime.
Inactive ingredients: Vial powder: L-arginine, sodium carbonate. Solvent ampoule: Water for Injections.
Mechanism of Action
Cefuroxime, a second-generation cephalosporin antibiotic, exerts its bactericidal effect by interfering with the synthesis of the bacterial cell wall, leading to cell death.
Pharmacological Properties
Cefuroxime has a broad spectrum of activity against susceptible bacteria, including both gram-positive and gram-negative organisms. It exhibits good tissue penetration and is stable in the presence of many beta-lactamases.
Indications for Use
Indicated for: Treatment of infections caused by susceptible bacteria, including lower respiratory tract, skin and skin structure, urinary tract, bone and joint, and intra-abdominal infections.
Contraindications
Contraindications: Hypersensitivity to cefuroxime or other cephalosporins. Use with caution in patients with a history of penicillin allergy due to potential cross-reactivity.
Side Effects
Common side effects may include gastrointestinal disturbances, allergic reactions, and superinfection. Severe adverse effects such as anaphylaxis and pseudomembranous colitis have been reported rarely.
Usage Instructions
Administration: Administer by intravenous or intramuscular injection after reconstituting the vial with the provided solvent. Dosage adjustments may be necessary based on the severity of the infection.
Benefits Compared to Analogues
Axsef offers the advantage of a broad antibacterial spectrum, good tissue penetration, and a favorable safety profile compared to some other cephalosporins.
Suitable Patient Groups
Axsef is suitable for use in both adult and pediatric populations, with dosage adjustments based on age and weight. It is also considered safe for elderly patients with appropriate monitoring.
Storage and Shelf Life
Store Axsef as per the manufacturer’s instructions, away from moisture and light. Check the expiration date on the packaging and do not use the product beyond this date.
Packaging Description
Axsef is available as a 750 mg vial of powder for reconstitution and solvent ampoules for injection. The packaging is designed to maintain the stability and sterility of the product.
Clinical Evidence and Proven Effectiveness
Clinical studies have demonstrated the efficacy of cefuroxime in the treatment of various infections, including community-acquired pneumonia and skin infections. Its favorable pharmacokinetic profile and clinical outcomes support its use as a reliable antibiotic option.
