Description
Azapin (Clozapine) Tablets 0.1g. №50
Ingredients
Active ingredient: Clozapine 0.1g per tablet.
Mechanism of Action
Clozapine exerts its antipsychotic effects through a combination of serotonin and dopamine receptor antagonism, particularly targeting the D4 receptor subtype. It also has potent anticholinergic, antihistaminic, and antiadrenergic properties.
Pharmacological Properties
Clozapine demonstrates high affinity for dopamine D4, serotonin 5-HT2, muscarinic, and alpha-adrenergic receptors. It exhibits a lower propensity for causing extrapyramidal symptoms compared to typical antipsychotics.
Indications for Use
Indications: Azapin tablets are indicated for the treatment of severe schizophrenia in patients who have not responded to standard treatments. It is particularly effective in managing treatment-resistant schizophrenia cases.
Contraindications
Contraindications: Azapin should not be used in individuals with a history of bone marrow suppression, uncontrolled epilepsy, or clozapine-induced agranulocytosis. Close monitoring is necessary in patients with pre-existing cardiac conditions.
Side Effects
Adverse effects: Common side effects of Azapin tablets include sedation, hypersalivation, weight gain, and potential metabolic disturbances. Rare but serious adverse effects include agranulocytosis and myocarditis.
Usage Instructions
Dosage: The usual starting dose is 12.5 mg once or twice daily, with gradual increments. The maintenance dose typically ranges from 300 to 450 mg per day, with a maximum dose of 900 mg daily. Dosage adjustments should be made based on individual response and tolerability.
Benefits Compared to Analogues
Clozapine stands out among antipsychotic medications due to its superior efficacy in managing treatment-resistant schizophrenia. It offers a unique advantage in reducing both positive and negative symptoms of the disorder, with a lower risk of extrapyramidal side effects compared to conventional antipsychotics.
Suitable Patient Groups
Azapin is beneficial for patients with refractory schizophrenia who have not responded adequately to other antipsychotic agents. It is particularly valuable for individuals with a history of poor treatment response, aggressive symptoms, or persistent psychotic manifestations.
Storage and Shelf Life
Azapin tablets should be stored in a cool, dry place away from direct sunlight. The shelf life of the product is typically 2 to 3 years from the manufacturing date. Ensure proper storage conditions to maintain the medication’s stability and efficacy.
Packaging Description
Azapin tablets are typically packaged in blister packs to ensure individual tablet integrity and protection from environmental factors. Each pack contains 50 tablets, with clear labeling of the active ingredient strength and dosage instructions.
Clinical Evidence and Proven Effectiveness
Clinical studies have shown: Clozapine’s efficacy in managing refractory schizophrenia is well-documented. Comparative trials have consistently demonstrated its superior effectiveness in reducing symptom severity and improving overall functioning in treatment-resistant patients. The unique pharmacological profile of clozapine contributes to its distinct therapeutic benefits in challenging cases of schizophrenia.
