Description

Azarga (brinzolamid, timolol) Eye Drops 5 ml

Ingredients

Active ingredients: Brinzolamide and Timolol. Inactive ingredients may include mannitol, carbomer, tyloxapol, and purified water.

Dosage

Dosage: The usual dose is 1 drop in the affected eye(s) twice daily.

Indications

Indications: Azarga eye drops are indicated for the reduction of intraocular pressure in patients with open-angle glaucoma or ocular hypertension.

Contraindications

Contraindications: Do not use Azarga if you are allergic to any of the ingredients, have asthma, severe chronic obstructive pulmonary disease, or certain heart conditions.

Directions

Directions: Administer 1 drop in the affected eye(s) twice daily. Do not touch the dropper tip to any surface to avoid contamination.

Scientific Evidence

Azarga combines two active ingredients, brinzolamide, and timolol, to effectively lower intraocular pressure. Brinzolamide inhibits carbonic anhydrase in the ciliary processes of the eye, reducing aqueous humor production. Timolol, a beta-blocker, further decreases intraocular pressure by reducing aqueous humor formation. Clinical studies have shown that the combination of these two agents in Azarga eye drops provides a significant reduction in intraocular pressure compared to monotherapy.

Additional Information

Azarga eye drops should be stored at room temperature away from light and moisture. Contact lenses should be removed before administration and can be reinserted after 15 minutes. It is important to follow the prescribed dosing schedule to achieve optimal therapeutic effects.

Pharmacological Effects: The dual mechanism of action of brinzolamide and timolol in Azarga eye drops targets different pathways involved in intraocular pressure regulation, providing a synergistic effect in lowering intraocular pressure.

Clinical Trials: Clinical trials have demonstrated the efficacy and safety of Azarga in reducing intraocular pressure in patients with glaucoma or ocular hypertension. A study by Xiong et al. (2018) showed that Azarga was well-tolerated and significantly reduced intraocular pressure compared to timolol alone.