Description
Azitromicin 500 (Azithromycin) Coated Tablets 500 mg. N3
Ingredients
Each coated tablet contains 500 mg of Azithromycin.
Mechanism of Action
Azithromycin, the active ingredient in Azitromicin 500 tablets, is a macrolide antibiotic that acts by binding to the 50S ribosomal subunit of susceptible bacteria. This binding inhibits protein synthesis, leading to the suppression of bacterial growth and reproduction.
Pharmacological Properties
Azithromycin exhibits bacteriostatic activity against a wide range of gram-positive, gram-negative, and atypical bacteria. It is well-absorbed orally and distributed to various tissues in the body, achieving high concentrations at the site of infection.
Indications for Use
Azitromicin 500 tablets are indicated for the treatment of bacterial infections caused by susceptible microorganisms. These infections may include respiratory tract infections, skin and soft tissue infections, and sexually transmitted diseases where Azithromycin is the appropriate choice based on susceptibility testing.
Contraindications
Azitromicin 500 should not be used in individuals with a known hypersensitivity to Azithromycin, other macrolide antibiotics, or any component of the formulation. Caution is advised in patients with a history of liver or renal impairment.
Side Effects
Common side effects of Azitromicin 500 may include gastrointestinal disturbances such as nausea, vomiting, diarrhea, and abdominal pain. Less frequently, individuals may experience headache, dizziness, and allergic reactions like rash or pruritus. Severe adverse effects are rare but may include hepatotoxicity and cardiac arrhythmias.
Usage Instructions
The typical dosage regimen involves taking one tablet (500 mg) orally once daily. The duration of treatment should be determined by a healthcare provider based on the type and severity of the infection. Azitromicin 500 tablets are best taken on an empty stomach with a full glass of water to enhance absorption.
Benefits Compared to Analogues
Azitromicin 500 offers the advantage of a convenient once-daily dosing schedule due to its extended half-life, which allows for effective bacterial eradication with fewer doses. Its broad spectrum of activity against various pathogens makes it a versatile choice for treating a range of infections.
Suitable Patient Groups
Azitromicin 500 is generally well-tolerated across different age groups, including pediatric and geriatric populations. However, dosage adjustments may be necessary in patients with hepatic or renal impairment to prevent drug accumulation and potential toxicity.
Storage and Shelf Life
Azitromicin 500 tablets should be stored at room temperature away from moisture and heat. The shelf life of the product is typically indicated on the packaging and should be checked before use to ensure potency and efficacy.
Packaging Description
Azitromicin 500 tablets are typically supplied in blister packs to protect the tablets from environmental factors and maintain their stability. Each pack contains a specified number of tablets as indicated on the packaging label.
