Description
Azitromicin (Azithromycin) Lyophilisate Powder for Injections 500 mg Vial №1
Ingredients
Each vial contains: Azithromycin (as azithromycin dihydrate) 500 mg.
Mechanism of Action
Azitromicin exerts its antibacterial effect by binding to the 50S ribosomal subunit of susceptible bacteria, thus inhibiting protein synthesis and ultimately leading to bacterial cell death.
Pharmacological Properties
Azitromicin is a broad-spectrum macrolide antibiotic with bacteriostatic activity against a wide range of Gram-positive, Gram-negative, and atypical bacteria.
Indications for Use
Azitromicin is indicated for the treatment of infections caused by susceptible strains of the designated microorganisms. These infections may include respiratory tract infections, skin and soft tissue infections, and sexually transmitted diseases.
Contraindications
This medication is contraindicated in patients with known hypersensitivity to azithromycin or any other macrolide antibiotics. It should be used with caution in patients with liver or kidney impairment.
Side Effects
Common side effects of azitromicin may include gastrointestinal disturbances, headache, and skin reactions. Serious but rare side effects may include cardiac arrhythmias and liver toxicity.
Usage Instructions
The dosage and duration of therapy should be determined by a healthcare provider. Azitromicin lyophilisate powder is typically reconstituted and administered intravenously. It is important to follow the instructions provided by the healthcare professional.
Benefits Compared to Analogues
Azitromicin is preferred in some cases due to its convenient dosing regimen, extended tissue distribution, and favorable tolerability profile compared to other macrolide antibiotics.
Suitable Patient Groups
Azitromicin can be used in various patient populations, including adults, children, and the elderly. Dosing adjustments may be necessary based on individual patient factors.
Storage and Shelf Life
- Storage: Store the lyophilisate powder for injections at room temperature away from light and moisture.
- Shelf Life: Check the expiration date on the packaging and do not use the product after the specified date.
Packaging Description
The product is supplied as a lyophilisate powder in a single-dose vial containing 500 mg of azithromycin. Each vial is for single use only and should be reconstituted as directed before administration.
Clinical Evidence and Proven Effectiveness
Azithromycin has been extensively studied and proven effective in the treatment of various bacterial infections. Research published in the Journal of Antimicrobial Chemotherapy demonstrated the efficacy of azithromycin in treating respiratory tract infections.
Clinical trials have shown that azithromycin is well-tolerated and has a favorable safety profile. A study published in the International Journal of Infectious Diseases highlighted the efficacy of azithromycin in the treatment of skin and soft tissue infections.
