Description
B12 (Cyanocobalamin) Solution for Injections 0.5 mg/ml. 1ml. Ampoules №10
Ingredients
Each 1ml ampoule contains 0.5 mg of Cyanocobalamin.
Mechanism of Action
Cyanocobalamin, a synthetic form of vitamin B12, plays a crucial role in DNA synthesis, red blood cell formation, and neurological function. Upon intramuscular injection, Cyanocobalamin is absorbed and utilized by the body to correct B12 deficiency.
Pharmacological Properties
Cyanocobalamin acts as a cofactor for methionine synthase and L-methylmalonyl-CoA mutase, enzymes essential for various metabolic pathways. It facilitates the conversion of homocysteine to methionine and methylmalonyl-CoA to succinyl-CoA, contributing to normal cell function and energy production.
Indications for Use
B12 injections are indicated for the treatment of vitamin B12 deficiency, pernicious anemia, and neuropathies associated with B12 deficiency. They are essential in cases where oral supplementation is ineffective or malabsorption issues are present.
Contraindications
Patients with polycythemia vera, Leber’s disease, or known hypersensitivity to cobalt or cyanocobalamin should not receive B12 injections due to the risk of adverse reactions or exacerbation of underlying conditions.
Side Effects
Common side effects of B12 injections may include injection site reactions, mild rash, or transient dizziness. In rare cases, allergic reactions or hypokalemia may occur. Monitoring for signs of hypokalemia is crucial in high-risk individuals.
Usage Instructions
The usual dosage is 0.5 mg injected intramuscularly once a day for 5-10 days to correct deficiency, followed by a maintenance dose of 0.5 mg every 1-3 months depending on the underlying condition and individual response.
Benefits Compared to Analogues
B12 injections offer a rapid and direct method of replenishing B12 levels, bypassing potential absorption issues in the gastrointestinal tract. This ensures effective correction of deficiency and faster symptom relief compared to oral supplementation, especially in cases of malabsorption.
Suitable Patient Groups
B12 injections are suitable for a wide range of patients, including those with malabsorption disorders, the elderly with reduced intrinsic factor production, individuals with pernicious anemia, and pediatric patients with B12 deficiency. However, individualized dosing and monitoring are essential for optimal outcomes.
Storage and Shelf Life
Store B12 ampoules in a cool, dry place away from light. Check the expiration date on the packaging and do not use expired products. Proper storage ensures the stability and efficacy of the solution throughout its shelf life.
Packaging Description
The product is available in ampoules, each containing 1ml of Cyanocobalamin solution at a concentration of 0.5 mg/ml. The ampoules are sealed to maintain sterility and should be handled with care to prevent breakage.
Clinical Evidence and Proven Effectiveness
Cyanocobalamin injections have demonstrated significant efficacy in raising vitamin B12 levels and improving associated symptoms in patients with deficiency. Clinical studies have shown a clear benefit in correcting B12 deficiency-related complications and enhancing overall well-being.
