Description
B12 (Cyanocobalamin) Solution for Injections Ampoules 0.05% 1ml. №10
Ingredients
Each 1ml ampoule contains 0.05% Cyanocobalamin (Vitamin B12).
Mechanism of Action
Cyanocobalamin, a form of Vitamin B12, plays a crucial role in DNA synthesis, red blood cell formation, and neurological function. It acts as a cofactor for methionine synthase, facilitating the conversion of homocysteine to methionine. This process is essential for the production of nucleic acids and myelin sheath maintenance in nerves.
Pharmacological Properties
- Essential for hematopoiesis and erythropoiesis
- Regulates neurological function
- Involved in the metabolism of fatty acids and amino acids
Indications for Use
B12 injections are indicated for the treatment of B12 deficiency, pernicious anemia, and certain types of neuropathies. They are essential in cases where oral supplementation is not effective or feasible.
Contraindications
Do not use B12 injections in individuals with known hypersensitivity to cyanocobalamin, cobalt, or any other component of the formulation. Caution is advised in patients with polycythemia vera due to the potential for exacerbation of erythropoiesis.
Side Effects
Common side effects may include injection site reactions, such as pain or redness. Rarely, allergic reactions or hypokalemia may occur. In very high doses, B12 injections could lead to hyperviscosity syndrome in patients with polycythemia vera.
Usage Instructions
The usual dosage is 1 ampoule injected intramuscularly once a day for up to 10 days, followed by a maintenance dose as directed by a healthcare professional. Administer the injection deep into the muscle. Do not inject intravenously.
Benefits Compared to Analogues
B12 injections offer a more direct and efficient route of administration compared to oral supplements, ensuring better absorption and bioavailability. This makes them particularly beneficial for individuals with malabsorption issues or severe deficiency requiring rapid correction.
Suitable Patient Groups
B12 injections are suitable for a wide range of patient groups, including individuals with malabsorption disorders, the elderly who may have reduced intrinsic factor production, vegetarians at risk of deficiency, and those with conditions requiring rapid replenishment of B12 levels.
Storage Conditions and Shelf Life
Store the ampoules in a cool, dry place away from light. Check the expiration date on the packaging and do not use the product if expired. Once opened, use the ampoule promptly to prevent contamination.
Packaging Description
The product is supplied in individual glass ampoules containing 1ml of 0.05% Cyanocobalamin solution for injection. Each box typically contains 10 ampoules for multiple doses.
Clinical Evidence and Proven Effectiveness
Studies have shown that B12 injections are effective in correcting B12 deficiency and improving symptoms associated with neuropathies. Research also suggests that B12 injections may have a more rapid onset of action compared to oral supplementation, making them a preferred choice in certain clinical situations.
Additional Information
It is important to monitor B12 levels regularly during treatment to ensure optimal dosing and efficacy. Consult a healthcare provider for personalized dosing recommendations and to discuss any potential side effects or interactions with other medications.
