Description

Candesar (candesartan cilexetil) tablets 8 mg. №10

Ingredients

Active ingredient: Candesartan cilexetil 8 mg.

Dosage

Dosage: The usual recommended dose is one tablet once a day. It is important to follow the dosage instructions provided by your healthcare provider.

Indications

Indications: Candesar tablets are indicated for the treatment of hypertension (high blood pressure) in adults and children aged 1 to 17 years.

Contraindications

Contraindications: Do not use Candesar if you are allergic to candesartan or any other ingredients in the tablets. It is also contraindicated in pregnancy.

Directions

Directions: Swallow the tablet whole with a glass of water. It can be taken with or without food, but it is important to take it consistently at the same time each day.

Scientific Evidence

Candesartan cilexetil, the active ingredient in Candesar tablets, is a selective angiotensin II receptor blocker that works by blocking the action of angiotensin II, a substance in the body that causes blood vessels to constrict. Several studies have demonstrated the efficacy of candesartan in lowering blood pressure and reducing the risk of cardiovascular events.

Additional Information

It is essential to monitor blood pressure regularly while taking Candesar tablets to ensure optimal control. In case of any side effects or concerns, consult your healthcare provider. Avoid alcohol and limit salt intake while on this medication.

Pharmacological Effects

Candesartan cilexetil exerts its antihypertensive effects by selectively blocking the binding of angiotensin II to the AT1 receptor, leading to vasodilation and decreased secretion of aldosterone. This results in reduced peripheral resistance and blood pressure. Additionally, candesartan has been shown to have protective effects on target organs such as the heart and kidneys.

Clinical Trials and Comparative Effectiveness

Clinical trials have demonstrated the efficacy of candesartan cilexetil in reducing blood pressure and improving cardiovascular outcomes. In comparative studies, candesartan has shown similar efficacy to other angiotensin II receptor blockers but with potentially fewer side effects. Research suggests that candesartan may offer benefits in certain patient populations, such as those with heart failure or diabetes.

References:
1. Sica D. Candesartan cilexetil: an update of its use in essential hypertension. Ther Clin Risk Manag. 2008;4(1):23-32.
2. Yusuf S, Teo KK, Pogue J, et al. Telmisartan, ramipril, or both in patients at high risk for vascular events. N Engl J Med. 2008;358(15):1547-1559.