Description

Captopres (captopril) tablets 12.5, №20

Ingredients

Active ingredient: Captopril 12.5mg per tablet.

Dosage

Dosage: The usual starting dose is 12.5mg taken 2 or 3 times daily. Dosage may be adjusted based on individual response.

Indications

Indicated for: Hypertension, heart failure, diabetic nephropathy, and left ventricular dysfunction post-myocardial infarction.

Contraindications

Contraindications: Do not use in patients with a history of angioedema related to previous ACE inhibitor therapy.

Directions

– Take Captopres tablets orally with or without food.
– Swallow the tablet whole with a glass of water.
– Follow the dosage instructions provided by your healthcare provider.

Scientific Evidence

Captopril, the active ingredient in Captopres tablets, is an ACE inhibitor that has been extensively studied for its efficacy in managing hypertension and heart failure. Research published in the Journal of the American College of Cardiology demonstrated the benefits of captopril in reducing cardiovascular events and improving outcomes in patients with heart failure. Additionally, a meta-analysis published in the Cochrane Database of Systematic Reviews highlighted the role of captopril in reducing mortality and morbidity in individuals with heart failure.

Additional Information

Captopres tablets are well-tolerated by most patients; however, common side effects may include dizziness, cough, and hyperkalemia. It is essential to monitor potassium levels regularly while on captopril therapy. Consult your healthcare provider for personalized advice and dosage adjustments.

Pharmacological Effects

Captopril works by inhibiting the angiotensin-converting enzyme (ACE), which is responsible for converting angiotensin I to angiotensin II. By blocking this enzyme, captopril reduces the production of angiotensin II, a potent vasoconstrictor, leading to vasodilation and decreased blood pressure. This mechanism of action makes captopril an effective medication for managing hypertension and heart failure.

Clinical Trials and Comparative Effectiveness

Numerous clinical trials have demonstrated the efficacy of captopril in improving outcomes in patients with various cardiovascular conditions. In comparative studies, captopril has shown similar effectiveness to other ACE inhibitors in reducing blood pressure and improving cardiac function. A study published in the European Heart Journal compared the efficacy of captopril with enalapril and lisinopril, showing comparable results in lowering blood pressure and reducing cardiovascular events.

Overall, Captopres (captopril) tablets 12.5 offer a well-established treatment option for individuals with hypertension, heart failure, and other cardiovascular conditions, supported by robust scientific evidence and clinical trials.