Description

Captopril Tablets 12.5 mg

Composition

Active ingredient: Captopril 12.5 mg per tablet.

Mechanism of Action

Captopril, an angiotensin-converting enzyme (ACE) inhibitor, works by inhibiting the conversion of angiotensin I to angiotensin II. This leads to vasodilation, decreased aldosterone secretion, and ultimately results in reduced blood pressure and improved cardiac function.

Pharmacological Properties

Captopril is rapidly absorbed after oral administration. It has a short half-life requiring multiple daily doses for optimal effect. The drug is mainly excreted through the kidneys.

Indications for Use

• Treatment of hypertension
• Management of heart failure
• Improvement of survival post-myocardial infarction

Contraindications

Avoid Captopril in the following cases:

• Pregnancy
• History of angioedema related to previous ACE inhibitor therapy
• Severe kidney disease

Side Effects

Common side effects of Captopril may include hypotension, cough, dizziness, hyperkalemia, and renal dysfunction. Serious but rare side effects include angioedema and agranulocytosis.

Usage Instructions

Take Captopril as directed by your healthcare provider. The usual starting dose is 12.5 mg taken 2-3 times daily. The dosage may be adjusted based on individual patient response.

Benefits Compared to Analogues

Captopril has been well-studied and shown to significantly reduce cardiovascular events and mortality rates in patients with heart failure compared to placebo. Its efficacy in managing hypertension and heart failure makes it a preferred choice in many clinical settings.

Suitable Patient Groups

Captopril is suitable for adult patients with hypertension, heart failure, or post-myocardial infarction. It may also be used in specific populations such as individuals with diabetes and renal impairment, under close medical supervision.

Storage and Shelf Life

Store Captopril tablets in a cool, dry place away from moisture and sunlight. Check the expiration date on the packaging and do not use the medication if expired.

Packaging Description

Captopril tablets are typically packaged in blister packs containing 20 tablets each. The packaging should be intact and sealed before use.

Clinical Evidence and Proven Effectiveness

Clinical studies have shown that Captopril effectively reduces blood pressure, improves cardiac function, and enhances survival rates in patients with heart failure. Notably, research published in the Journal of the American College of Cardiology demonstrated the significant benefits of Captopril in reducing cardiovascular events and mortality.