Description

Casark HD (Candesartan Cilexetil and Hydrochlorothiazide) Tablets 32 mg/25 mg. №30

Composition

The active ingredients in Casark HD tablets are Candesartan Cilexetil 32 mg and Hydrochlorothiazide 25 mg.

Mechanism of Action

Candesartan Cilexetil is an angiotensin II receptor blocker (ARB) that works by blocking the action of angiotensin II, a substance in the body that causes blood vessels to constrict. Hydrochlorothiazide is a thiazide diuretic that helps the kidneys remove more sodium and water from the bloodstream, reducing blood volume and lowering blood pressure.

Pharmacological Properties

Casark HD combines the antihypertensive properties of Candesartan Cilexetil with the diuretic effects of Hydrochlorothiazide, resulting in a synergistic reduction of blood pressure. Candesartan Cilexetil selectively blocks the angiotensin II receptor subtype AT1, leading to vasodilation and decreased secretion of aldosterone. Hydrochlorothiazide enhances the diuretic effect by inhibiting sodium reabsorption in the distal convoluted tubule.

Indications for Use

Casark HD tablets are indicated for the treatment of hypertension (high blood pressure). They are suitable for use as monotherapy or in combination with other antihypertensive agents to achieve optimal blood pressure control.

Contraindications

Casark HD is contraindicated in patients with severe renal impairment, hypersensitivity to Candesartan Cilexetil, Hydrochlorothiazide, or any other component of the formulation, and anuria. It should not be used during pregnancy or lactation due to potential risks to the fetus or infant.

Side Effects

Common side effects of Casark HD may include dizziness, hypotension, electrolyte imbalances, and renal dysfunction. Patients should be monitored for signs of adverse effects and instructed to report any unusual symptoms to their healthcare provider.

Usage Instructions

• Take one Casark HD tablet daily as prescribed by your healthcare provider.
• Avoid exceeding the recommended dosage to prevent adverse effects.
• Swallow the tablet whole with a glass of water at the same time each day for consistent blood pressure control.

Before initiating Casark HD or making any changes to your medication regimen, consult your healthcare provider for personalized guidance and monitoring.

Benefits Compared to Analogues

Casark HD offers the combined benefits of Candesartan Cilexetil and Hydrochlorothiazide in a single tablet, providing synergistic blood pressure-lowering effects with potentially fewer side effects compared to using each medication separately. The convenience of a once-daily dosing regimen enhances patient compliance and treatment adherence.

Suitable Patient Groups

Casark HD is suitable for adult patients with hypertension requiring dual therapy for blood pressure management. It may be used in elderly patients under careful monitoring and dose adjustment based on individual response. The safety and efficacy of Casark HD in children have not been established.

Storage and Shelf Life

Store Casark HD tablets in a cool, dry place away from direct sunlight and moisture. Keep the medication out of reach of children and pets. Check the expiration date on the packaging and do not use the tablets beyond the specified shelf life.

Packaging Description

Casark HD tablets are available in a pack containing 30 tablets. Each tablet is film-coated for ease of swallowing and protection from degradation. The packaging is designed to maintain the integrity and stability of the tablets until the expiration date.