Description
Cefazolin (Cefazolin) Powder for Solution for Injections 1g. №5
Composition
The main active ingredient in this product is Cefazolin, a broad-spectrum antibiotic from the cephalosporin group.
Mechanism of Action
Cefazolin works by inhibiting bacterial cell wall synthesis, leading to the death of susceptible bacteria.
Pharmacological Properties
Cefazolin exhibits bactericidal activity against a wide range of gram-positive and some gram-negative bacteria. It is stable in the presence of beta-lactamases and is effective in treating infections caused by susceptible organisms.
Indications for Use
Cefazolin is indicated for the treatment of the following infections caused by susceptible bacteria:
- Respiratory tract infections
- Urinary tract infections
- Skin and soft tissue infections
- Bone and joint infections
Contraindications
Cefazolin is contraindicated in patients with a known allergy to cephalosporin antibiotics. It should not be used in patients with severe kidney disease due to the risk of nephrotoxicity.
Side Effects
Common side effects of Cefazolin may include gastrointestinal disturbances, allergic reactions, and injection site reactions. Rare but serious adverse effects may include pseudomembranous colitis and anaphylaxis.
Usage Instructions
To prepare the solution, reconstitute the powder with sterile water for injection. The reconstituted solution should be used immediately and should not be used if it appears cloudy or contains particles. The dosage of Cefazolin typically ranges from 1g to 2g administered intravenously or intramuscularly every 6 to 8 hours, depending on the severity of the infection.
Benefits Compared to Analogues
Cefazolin offers advantages over some other antibiotics due to its broad-spectrum activity, stability against beta-lactamases, and established efficacy in treating various bacterial infections.
Suitable Patient Groups
Cefazolin can be used in both adult and pediatric populations. Dosing adjustments may be necessary in elderly patients or those with renal impairment to prevent adverse effects.
Storage and Shelf Life
Cefazolin should be stored at room temperature away from light and moisture. The shelf life of the product is typically indicated on the packaging and should be checked before use.
Packaging Description
Cefazolin is available in powder form for reconstitution and is typically packaged in vials containing 1g of the active ingredient. Each package may contain a specific number of vials for single-use administration.
