Description
Cefepim (Cefepime) Powder for Solution for Injections 1g. №1 Vial
Composition
The main active ingredient in this product is cefepime, a fourth-generation cephalosporin antibiotic with a broad spectrum of activity against various bacteria.
Mechanism of Action
Cefepime exerts its bactericidal effect by inhibiting bacterial cell wall synthesis through binding to penicillin-binding proteins (PBPs). This leads to disruption of the cell wall integrity, ultimately causing bacterial cell death.
Pharmacological Properties
Cefepime demonstrates excellent stability against most beta-lactamases and has enhanced activity against Gram-negative bacteria. It also exhibits good penetration into tissues and achieves high concentrations in the lungs, skin, and urinary tract.
Indications for Use
Cefepime is indicated for the treatment of various bacterial infections, including:
- Pneumonia
- Skin and soft tissue infections
- Urinary tract infections
- Intra-abdominal infections
Contraindications
Avoid using Cefepime if you have a known allergy to cefepime, other cephalosporins, or beta-lactam antibiotics. Anaphylactic reactions may occur in individuals with hypersensitivity to these agents.
Side Effects
Common side effects of Cefepime may include gastrointestinal disturbances, hypersensitivity reactions, and superinfection. Serious adverse effects such as Clostridium difficile-associated diarrhea and central nervous system toxicity are rare but possible.
Usage Instructions
Cefepime is intended for intravenous administration after reconstitution with a compatible diluent. The recommended dosage varies based on the type and severity of the infection, typically ranging from 1g to 2g every 12 hours. Patients should follow the instructions provided by healthcare professionals closely.
Benefits Compared to Analogues
Cefepime offers several advantages over older cephalosporins, including broader antibacterial coverage, increased resistance to beta-lactamases, and enhanced stability against certain bacterial enzymes. Its pharmacokinetic profile allows for less frequent dosing in some cases.
Suitable Patient Groups
Cefepime is generally well-tolerated across different age groups, including pediatric and elderly patients. Dosing adjustments may be necessary in individuals with renal impairment to prevent drug accumulation and potential toxicity.
Storage and Shelf Life
Store Cefepime vials in a cool, dry place away from light. Once reconstituted, the solution should be used promptly or refrigerated at recommended temperatures. Check the expiration date on the packaging and do not use expired products.
Packaging Description
Cefepime is supplied as a powder for solution in single-dose vials. Each vial contains 1g of cefepime for reconstitution. The packaging is designed to maintain sterility and protect the product from external contaminants.
