Description
Cefimek (Cefepime) Solution Powder 1g. №1
Composition
The main active ingredient in Cefimek is cefepime, a potent fourth-generation cephalosporin antibiotic known for its broad-spectrum activity against various bacterial pathogens.
Mechanism of Action
Cefepime exerts its bactericidal effect by inhibiting bacterial cell wall synthesis through binding to penicillin-binding proteins (PBPs), leading to cell lysis and eventual bacterial death.
Pharmacological Properties
Cefepime demonstrates high stability against beta-lactamases, ensuring efficacy against resistant bacterial strains. It exhibits excellent tissue penetration and a prolonged half-life, allowing for convenient dosing regimens.
Indications for Use
Cefimek is indicated for the treatment of various bacterial infections, such as pneumonia, urinary tract infections, skin infections, and intra-abdominal infections caused by susceptible organisms.
Contraindications
Cefimek is contraindicated in individuals with a history of hypersensitivity to cefepime or other cephalosporins. Additionally, it should be avoided in patients with renal impairment due to the risk of potential nephrotoxicity.
Side Effects
Common side effects of Cefimek may include gastrointestinal disturbances, hypersensitivity reactions, and superinfections. Monitoring for adverse effects is essential during therapy.
Usage Instructions
Cefimek should be administered intravenously after reconstitution of the powder with sterile water according to the healthcare provider’s instructions. Dosage adjustments may be necessary based on the severity of the infection and renal function.
Benefits Compared to Analogues
Cefimek offers the advantage of a broad antibacterial spectrum and increased stability against beta-lactamases compared to earlier cephalosporins. Its extended half-life allows for less frequent dosing, enhancing patient compliance.
Suitable Patient Groups
Cefimek can be used in both adult and pediatric populations, with dosages adjusted based on weight and age. Special caution is advised when administering to elderly patients and those with compromised renal function.
Storage and Shelf Life
Cefimek should be stored at controlled room temperature away from moisture and light. The shelf life of the reconstituted solution is limited; any unused portion should be discarded after the recommended time frame.
Packaging Description
Cefimek is supplied as a single-dose vial containing 1g of cefepime powder for reconstitution. Each vial is labeled with the necessary instructions for preparation and administration.
