Description
Cefoctam (Cefuroxime) Powder for Solution for Injections 1.5g Vial
Composition
The active ingredient in each vial of Cefoctam is Cefuroxime, a potent antibiotic belonging to the cephalosporin class, effective against a wide range of bacterial infections.
Mechanism of Action
Cefuroxime exerts its bactericidal effect by inhibiting bacterial cell wall synthesis, leading to cell death. It specifically targets and disrupts the formation of peptidoglycan layers in bacterial cell walls, resulting in the lysis of the microorganisms.
Pharmacological Properties
As a second-generation cephalosporin, Cefuroxime demonstrates broad-spectrum activity against both Gram-positive and Gram-negative bacteria. It exhibits high stability to beta-lactamases, enhancing its efficacy against resistant strains. The drug is well-absorbed after intravenous administration, reaching therapeutic concentrations rapidly.
Indications for Use
Cefoctam is indicated for the treatment of severe bacterial infections caused by susceptible pathogens. It is commonly prescribed for conditions such as pneumonia, urinary tract infections, skin and soft tissue infections, and meningitis.
Contraindications
Cefoctam is contraindicated in patients with a known hypersensitivity to cefuroxime or other cephalosporins due to the risk of severe allergic reactions, including anaphylaxis. Additionally, individuals with a history of significant renal impairment should avoid its use to prevent potential nephrotoxic effects.
Side Effects
Common side effects of Cefoctam may include gastrointestinal disturbances like nausea, vomiting, and diarrhea. Allergic reactions such as rash, itching, and swelling can occur, requiring immediate medical attention. In rare cases, the drug may lead to severe adverse effects like pseudomembranous colitis or anaphylactic shock.
Usage Instructions
Cefoctam is intended for intravenous administration and should be reconstituted with sterile water for injection as per the instructions provided. The recommended adult dosage typically involves administering 1.5g every 8 hours, with adjustments made for pediatric patients based on weight and severity of the infection. The reconstituted solution must be further diluted before use and should be infused immediately after preparation to maintain potency.
Benefits Over Analogues
Compared to other antibiotics, Cefoctam offers the advantage of a broad antibacterial spectrum, encompassing both common and resistant strains. Its stability against beta-lactamases enhances its effectiveness in combating multidrug-resistant infections, making it a valuable choice in clinical practice.
Suitable Patient Groups
Cefoctam is suitable for use in both adult and pediatric populations, with dosages adjusted based on age, weight, and renal function. The drug is generally well-tolerated in elderly patients, although caution is advised in those with compromised renal or hepatic function to prevent adverse reactions.
Storage and Shelf Life
Cefoctam should be stored at controlled room temperature away from light and moisture. The powder for solution for injections has a specified shelf life indicated on the packaging, and expired or discolored vials should not be used.
Packaging Description
The product is supplied in vials containing 1.5g of Cefoctam powder for reconstitution. Each vial is labeled with the necessary information regarding the drug name, active ingredient, dosage strength, and storage conditions. The packaging ensures the integrity and sterility of the product until use.
