Description
Cefotaxim (Cefotaxime) Powder 1g. №1 Vial
Composition
The active ingredient in this product is Cefotaxime, a third-generation cephalosporin antibiotic.
Mechanism of Action
Cefotaxime exerts its antibacterial effect by inhibiting the synthesis of bacterial cell walls, leading to cell death. It acts by binding to penicillin-binding proteins, thereby disrupting the cross-linking of peptidoglycans.
Pharmacological Properties
Cefotaxime demonstrates broad-spectrum activity against Gram-positive and Gram-negative bacteria. It is stable in the presence of beta-lactamases, making it effective against many resistant strains. The drug is well-absorbed after parenteral administration and reaches therapeutic concentrations in various tissues and body fluids.
Indications for Use
Cefotaxime is indicated for the treatment of various bacterial infections, including:
- Respiratory tract infections
- Urinary tract infections
- Skin and soft tissue infections
- Bone and joint infections
- Gynecological infections
Contraindications
Avoid using Cefotaxime if you have a history of hypersensitivity to cefotaxime, other cephalosporins, or any components of the formulation. Anaphylactic reactions may occur in susceptible individuals.
Side Effects
Common side effects of Cefotaxime may include gastrointestinal disturbances, allergic reactions, and local injection site reactions. Severe adverse effects such as pseudomembranous colitis or anaphylaxis are rare but possible.
Usage Instructions
Cefotaxime is typically administered via intravenous or intramuscular routes. The dosage and duration of treatment should be determined by the severity of the infection and the patient’s condition. It is crucial to adhere to the prescribed dosing regimen and complete the full course of therapy to achieve optimal outcomes.
Benefits Compared to Analogues
Cefotaxime offers several advantages over older cephalosporins, including enhanced activity against resistant bacteria, broader spectrum coverage, and lower susceptibility to beta-lactamases. Its pharmacokinetic profile allows for convenient dosing regimens and effective penetration into target tissues.
Suitable Patient Groups
Cefotaxime can be used in various patient populations, including pediatric and geriatric patients. Dosing adjustments may be necessary based on age, renal function, and the specific indication for treatment. Close monitoring is essential to ensure therapeutic efficacy and minimize the risk of adverse events.
Storage and Shelf Life
Store Cefotaxime vials at the recommended temperature and protect from light. Check the expiration date before use and discard any expired or discolored products. Proper storage conditions help maintain the stability and potency of the medication throughout its shelf life.
Packaging Description
Each vial of Cefotaxime powder contains 1g of the active ingredient and is designed for single-use administration. The packaging should be intact and sterile before preparation and injection. Follow proper aseptic techniques during reconstitution to prevent contamination.
