Description
Celebrex (celecoxib) Capsules 200 mg. №20
Composition
The active ingredient in Celebrex capsules is celecoxib 200 mg. Inactive ingredients include lactose monohydrate, sodium lauryl sulfate, povidone, and magnesium stearate.
Mechanism of Action
Celecoxib, the active ingredient in Celebrex, is a selective COX-2 inhibitor that exerts its anti-inflammatory, analgesic, and antipyretic effects by inhibiting the enzyme cyclooxygenase-2.
Pharmacological Properties
Celebrex exhibits anti-inflammatory, analgesic, and antipyretic properties. It selectively inhibits COX-2, reducing the production of prostaglandins involved in inflammation and pain pathways.
Indications for Use
Celebrex (celecoxib) is indicated for the management of acute pain in adults, treatment of primary dysmenorrhea, and relief of signs and symptoms of osteoarthritis and rheumatoid arthritis.
Contraindications
Celebrex (celecoxib) should not be used by patients with known allergic reactions to sulfonamides, aspirin, or other NSAIDs. It is contraindicated in patients with a history of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs.
Side Effects
Common side effects of Celebrex may include gastrointestinal discomfort, headache, dizziness, and peripheral edema. Serious side effects such as cardiovascular events and gastrointestinal bleeding may occur.
Usage Instructions
The recommended dosage of Celebrex (celecoxib) is 200 mg daily, either as a single dose or divided into two doses. It should be taken with food, swallowed whole with water, and not chewed, crushed, or broken.
Benefits Compared to Analogues
Celebrex offers the advantage of selective COX-2 inhibition, potentially reducing the risk of gastrointestinal side effects compared to non-selective NSAIDs.
Suitable Patient Groups
Celebrex can be used in adult patients for various indications. Caution is advised in the elderly population and those with preexisting cardiovascular conditions.
Storage and Shelf Life
Celebrex capsules should be stored at room temperature away from moisture and heat. The shelf life of the product is typically indicated on the packaging.
Packaging Description
Celebrex capsules are typically available in packs containing 20 capsules of 200 mg strength each. The packaging may include information on dosage instructions, contraindications, and side effects.
