Description
Cerucal (Metoclopramide) Tablets 10 mg. №50
Composition
Each Cerucal tablet contains 10 mg of metoclopramide as the active ingredient. Other ingredients include lactose, magnesium stearate, and microcrystalline cellulose.
Mechanism of Action
Metoclopramide exerts its effects as a dopamine antagonist and a prokinetic agent. It stimulates gastric emptying and accelerates intestinal transit by enhancing acetylcholine release.
Pharmacological Properties
Metoclopramide acts on the upper digestive tract, reducing reflux and increasing lower esophageal sphincter tone. It also has antiemetic properties by blocking dopamine receptors in the chemoreceptor trigger zone.
Indications for Use
- Relief of symptoms associated with acute and recurrent diabetic gastric stasis.
- Prevention of nausea and vomiting associated with emetogenic cancer chemotherapy.
- Prevention of postoperative nausea and vomiting.
Contraindications
Cerucal (Metoclopramide) tablets are contraindicated in patients with:
- Pheochromocytoma or other catecholamine-releasing paragangliomas.
- Known sensitivity or allergy to metoclopramide.
- Seizure disorders.
Side Effects
Common side effects of Cerucal (Metoclopramide) tablets may include drowsiness, restlessness, extrapyramidal symptoms, and gastrointestinal disturbances. Rare but serious side effects include tardive dyskinesia and neuroleptic malignant syndrome.
Usage Instructions
Take Cerucal (Metoclopramide) tablets orally with a full glass of water. The recommended dosage is 10 mg, three times daily. Tablets should be taken 30 minutes before meals and at bedtime. Do not crush or chew the tablets.
Benefits Compared to Analogues
Cerucal (Metoclopramide) offers advantages over other prokinetic agents due to its combined antiemetic and gastroprokinetic effects, making it a versatile option for various gastrointestinal conditions.
Suitable Patient Groups
Cerucal (Metoclopramide) tablets can be used in adult patients, including the elderly, for the management of gastrointestinal motility disorders. Caution is advised in pediatric patients due to the risk of extrapyramidal symptoms.
Storage and Shelf Life
Store Cerucal (Metoclopramide) tablets in a cool, dry place away from direct sunlight. Keep the tablets in their original packaging to protect from moisture. Check the expiration date on the packaging and do not use after the specified date.
Packaging Description
Cerucal (Metoclopramide) tablets are packaged in blister packs of 50 tablets each. The packaging is designed to maintain the stability and integrity of the tablets until use.
