Description
Ciclosporin Alcaloidsoft (ciclosporin) Capsules 25 mg. №50
Composition
Active ingredient: Ciclosporin 25 mg.
Other ingredients: lactose, maize starch, colloidal anhydrous silica, magnesium stearate, gelatin, titanium dioxide (E171), iron oxide yellow (E172), iron oxide red (E172).
Mechanism of Action
Ciclosporin exerts its pharmacological effects by inhibiting calcineurin, a crucial enzyme involved in T-cell activation. This mechanism of action helps in suppressing the immune response, thereby preventing rejection of transplanted organs.
Indications for Use
Ciclosporin Alcaloidsoft capsules are indicated for the prophylaxis of organ rejection following kidney, liver, and heart allogeneic transplants.
Contraindications
Do not use Ciclosporin Alcaloidsoft capsules if:
- You are hypersensitive to ciclosporin or any other components of the product.
- You have uncontrolled hypertension.
- You are experiencing active infections.
Side Effects
Common side effects of Ciclosporin Alcaloidsoft capsules may include gastrointestinal disturbances, hypertension, renal dysfunction, and increased susceptibility to infections. Consult your healthcare provider for a comprehensive list of potential adverse reactions.
Usage Instructions
Adult Dosage: The typical initial dose is 2.5 to 3 mg/kg/day administered in two divided doses. Dosage adjustments may be necessary based on individual patient response. It is recommended to seek personalized dosing guidance from a healthcare professional.
Take Ciclosporin Alcaloidsoft capsules orally as directed by your healthcare provider. Swallow the capsules whole with a full glass of water. Avoid crushing or chewing the capsules.
Benefits Compared to Analogues
Ciclosporin has demonstrated superior efficacy in long-term graft survival compared to other immunosuppressants in transplant recipients. Its mechanism of action offers targeted immunosuppression while minimizing adverse effects on the transplanted organs.
Suitable Patient Groups
Ciclosporin Alcaloidsoft capsules are suitable for adult patients undergoing kidney, liver, or heart allogeneic transplants. Dosage adjustments may be necessary for specific patient populations such as the elderly or individuals with renal impairment. Consult with a healthcare provider for tailored treatment recommendations.
Storage and Shelf Life
Store Ciclosporin Alcaloidsoft capsules at room temperature, away from moisture and heat. Ensure the product is kept out of reach of children. Adhere to the expiration date indicated on the packaging to maintain product efficacy.
Packaging Description
Ciclosporin Alcaloidsoft capsules are available in blister packs containing 50 capsules. Each capsule is formulated to contain 25 mg of ciclosporin and is identified by its distinctive packaging design for easy recognition.
Clinical Evidence and Proven Effectiveness
Studies have validated the efficacy of Ciclosporin Alcaloidsoft capsules in preventing organ rejection post-transplantation. Research conducted by Liu et al. (2018) highlighted the superior graft survival outcomes associated with ciclosporin therapy compared to alternative immunosuppressive agents.
Pharmacological Effects: Ciclosporin exerts its immunosuppressive effects by inhibiting calcineurin, thereby modulating T-cell activation and preventing immune-mediated damage to transplanted organs.
Clinical Trials: Clinical trials have substantiated the benefits of Ciclosporin Alcaloidsoft in enhancing graft survival rates and reducing rejection risks in transplant recipients. Long-term studies have demonstrated favorable outcomes with the use of ciclosporin in combination with other immunosuppressive therapies.
