Description

Ciprolet (Ciprofloxacin) Coated Tablets 500 mg. №10

Ingredients:

Each coated tablet contains 500 mg of ciprofloxacin.

Mechanism of Action:

Ciprofloxacin, the active ingredient in Ciprolet tablets, is a fluoroquinolone antibiotic that exerts its bactericidal effect by inhibiting the bacterial DNA gyrase enzyme. This inhibition prevents DNA supercoiling and replication, ultimately leading to bacterial cell death.

Pharmacological Properties:

Ciprofloxacin demonstrates broad-spectrum antibacterial activity against both Gram-positive and Gram-negative bacteria. It is well-absorbed orally and reaches therapeutic concentrations in various tissues and body fluids.

Indications for Use:

Ciprolet tablets are indicated for the treatment of bacterial infections such as urinary tract infections, respiratory tract infections, skin and soft tissue infections, and bone and joint infections caused by susceptible pathogens.

Contraindications:

Do not use Ciprolet if you have a history of hypersensitivity to ciprofloxacin, other quinolone antibiotics, or any component of the formulation. Avoid use in patients with a history of tendon disorders related to fluoroquinolone use.

Side Effects:

Common side effects of Ciprolet may include gastrointestinal disturbances (nausea, diarrhea), headache, and dizziness. Serious adverse reactions such as tendon rupture, peripheral neuropathy, and central nervous system effects have been reported rarely. Patients should be monitored for any signs of adverse events during treatment.

Usage Instructions:

The usual dosage of Ciprolet is one 500 mg tablet taken orally twice daily. Dosage adjustments may be necessary in patients with renal impairment. Tablets should be swallowed whole with an adequate amount of water, and they should not be crushed or chewed.

Benefits Compared to Analogues:

Ciprofloxacin offers the advantage of a broad spectrum of activity against various bacteria, including many multidrug-resistant strains. Its oral formulation provides convenient dosing and good bioavailability, making it a preferred choice for the treatment of diverse bacterial infections.

Suitable Patient Groups:

Ciprolet can be used in adult patients, including the elderly, for the management of bacterial infections. Dosage adjustments based on renal function may be necessary in elderly individuals or those with impaired kidney function. The safety and efficacy of Ciprolet in pediatric populations have not been established.

Storage and Shelf Life:

• Storage: Keep Ciprolet tablets at room temperature, protected from moisture and heat.
• Shelf Life: Check the expiry date on the packaging and do not use the tablets after the stated expiration date.

Packaging Description:

Ciprolet tablets are typically packaged in blister packs to protect them from external factors such as light and moisture. Each pack contains a specified number of tablets as indicated by the packaging information.

Clinical Evidence and Proven Effectiveness:

Clinical studies have shown the efficacy of ciprofloxacin in treating various bacterial infections. For instance, a study published in the Journal of Antimicrobial Chemotherapy demonstrated the high effectiveness of ciprofloxacin in treating urinary tract infections caused by multidrug-resistant bacteria. The broad-spectrum activity and favorable pharmacokinetic profile of ciprofloxacin contribute to its clinical utility in diverse infection scenarios.