Description

Citicolin Solution for Injections 500 mg/4 ml. 4 ml. Ampoules №10

Ingredients:

Each 4 ml ampoule contains 500 mg of Citicoline.

Mechanism of Action:

Citicolin, also known as CDP-choline, is a prodrug of choline that plays a crucial role in the biosynthesis of phospholipids in cell membranes. It acts by providing choline for acetylcholine synthesis and supporting neuronal membrane repair and function.

Pharmacological Properties:

Citicolin exerts neuroprotective effects by stabilizing cell membranes, enhancing mitochondrial function, and promoting the synthesis of phospholipids. It also increases dopamine receptor densities in the brain, which may contribute to its cognitive-enhancing properties.

Indications for Use:

Citicolin is indicated for the treatment of acute ischemic stroke, traumatic brain injury, and cognitive disorders associated with neurodegenerative conditions such as Alzheimer’s disease and vascular dementia.

Contraindications:

Avoid using Citicolin if you have a known allergy to any of its components or if you have a history of hypersensitivity reactions to cholinergic agents.

Side Effects:

Common side effects of Citicolin may include gastrointestinal disturbances such as nausea, mild headache, and transient insomnia. If any severe or persistent adverse reactions occur, discontinue use and seek medical advice promptly.

Usage Instructions:

The recommended dosage of Citicolin is 500 mg (1 ampoule) administered via intramuscular or intravenous injection once or twice daily. Dilute the solution before administration and infuse slowly over 3-5 minutes under healthcare professional supervision.

Benefits Compared to Analogues:

Citicolin stands out from other choline-containing compounds due to its high bioavailability and ability to cross the blood-brain barrier efficiently. Its neuroprotective and cognitive-enhancing effects have been well-documented in clinical studies, making it a valuable therapeutic option for various neurological conditions.

Suitable Patient Groups:

Citicolin can be safely used in diverse patient populations, including adults of all ages, elderly individuals experiencing cognitive decline, and pediatric patients with neurological disorders. However, dosage adjustments may be necessary based on individual health status and treatment response.

Storage and Shelf Life:

• Storage: Keep Citicolin solution for injections in a cool, dry place away from direct sunlight to maintain its stability and efficacy.
• Shelf Life: Check the expiration date on the packaging and do not use the product beyond the stated shelf life to ensure safety and potency.

Packaging Description:

The product is available in boxes containing 10 ampoules, each filled with 4 ml of Citicolin solution for injections. The ampoules are sealed to prevent contamination and ensure sterility until use.