Description

Clexane (enoxaparin) 300 Solution for Injections 10000 IU 3 ml. №1 Vial

Ingredients

Active ingredient: Enoxaparin sodium.
Other ingredients: Water for injections.

Dosage

Dosage: The usual dose of Clexane is **100 IU** anti-Xa activity per kg body weight given **twice daily**.

Indications

Indications: Clexane is indicated for the prevention of deep vein thrombosis and pulmonary embolism.

Contraindications

Contraindications: Do not use Clexane if you are allergic to enoxaparin or heparin.

Directions

Directions: Clexane is administered by injection under the skin. Follow the instructions provided by your healthcare provider.

Scientific Evidence

Clexane (enoxaparin) has been extensively studied for its efficacy in preventing and treating thromboembolic disorders. Research published in the *New England Journal of Medicine* has shown that enoxaparin is as effective as unfractionated heparin in the treatment of deep vein thrombosis.

Additional Information

It is important to monitor platelet counts regularly during treatment with Clexane to detect any signs of thrombocytopenia. Inform your healthcare provider about any unusual bleeding or bruising while using this medication.

Pharmacological Effects

Enoxaparin, the active ingredient in Clexane, is a low molecular weight heparin that works by inhibiting the formation of blood clots. It primarily targets factor Xa, a key enzyme in the coagulation cascade, thereby preventing the conversion of prothrombin to thrombin and ultimately reducing the risk of clot formation.

Clinical Trials and Comparative Effectiveness

Clinical trials have demonstrated the efficacy of Clexane in various clinical settings, including in the prevention of venous thromboembolism in patients undergoing orthopedic surgery. Compared to other anticoagulants, enoxaparin has shown similar effectiveness but with potentially fewer side effects, making it a preferred choice in many clinical scenarios.

Clexane (enoxaparin) 300 Solution for Injections is a trusted medication with a well-established efficacy and safety profile in the management of thromboembolic disorders. Its pharmacological action, supported by scientific evidence and clinical trials, highlights its importance in preventing serious complications associated with blood clot formation.