Description

Climodien (estradiol valerate, dienogest) Coated Tablets №28

Ingredients:

Each tablet contains: Estradiol valerate and dienogest as active ingredients.

Dosage:

The recommended dosage is one tablet daily for 28 days. Follow the instructions provided by your healthcare provider.

Indications:

Climodien tablets are indicated for hormone replacement therapy in postmenopausal women. They help relieve symptoms of menopause such as hot flashes, vaginal dryness, and mood swings.

Contraindications:

Do not use Climodien if you have a history of breast cancer, liver disease, or unexplained vaginal bleeding. Consult your doctor before starting this medication.

Directions:

Take one tablet daily with water at the same time each day. Do not skip doses. If you miss a dose, take it as soon as you remember.

Scientific Evidence:

Studies have shown that the combination of estradiol valerate and dienogest in Climodien tablets effectively reduces menopausal symptoms and improves quality of life in postmenopausal women. The hormonal balance achieved with this medication helps alleviate vasomotor symptoms and genitourinary atrophy.

Additional Information:

Climodien tablets have been well-tolerated in clinical trials, with common side effects including headache, breast tenderness, and nausea. It is important to attend regular follow-up appointments with your healthcare provider while taking this medication to monitor your response and adjust the dosage if needed.

The pharmacological action of estradiol valerate involves binding to estrogen receptors in various tissues, leading to the activation of specific genes and regulation of target proteins. Dienogest complements this action by providing progestogenic effects, balancing the estrogenic activity and reducing the risk of endometrial hyperplasia.