Description
Clivas 20 (Rosuvastatin) Coated Tablets 20 mg. №30
Composition
Each tablet contains 20 mg of rosuvastatin.
Mechanism of Action
Rosuvastatin, a statin medication, works by inhibiting the enzyme HMG-CoA reductase, which plays a key role in cholesterol production in the liver. By reducing cholesterol synthesis, rosuvastatin helps lower total cholesterol and triglyceride levels in the blood.
Pharmacological Properties
Rosuvastatin is a selective and competitive inhibitor of HMG-CoA reductase. It decreases total cholesterol, LDL cholesterol, and triglycerides while increasing HDL cholesterol levels. It also has anti-inflammatory and endothelial function-improving properties.
Indications for Use
Clivas 20 is indicated for the treatment of hypercholesterolemia and hypertriglyceridemia in adults to reduce the risk of cardiovascular events such as heart attacks and strokes.
Contraindications
Avoid using Clivas 20 if you are pregnant, breastfeeding, have active liver disease, or have a known hypersensitivity to rosuvastatin or any of the tablet’s components.
Side Effects
Common side effects of Clivas 20 may include headache, muscle aches, abdominal pain, and constipation. Rare but serious side effects may include myopathy (muscle disease) and rhabdomyolysis (muscle breakdown).
Usage Instructions
The recommended dosage of Clivas 20 is one 20 mg tablet taken orally once daily. It can be taken with or without food. Follow the instructions provided by your healthcare provider for optimal results.
Benefits Compared to Analogues
Clivas 20, containing rosuvastatin, offers the advantage of potent cholesterol-lowering effects with a favorable safety profile compared to other statins. It has been shown to effectively reduce LDL cholesterol and triglycerides while potentially providing additional cardiovascular benefits.
Suitable Patient Groups
Clivas 20 is suitable for use in adult patients with hyperlipidemia. It is not recommended for pregnant or breastfeeding women, individuals with active liver disease, or those with a history of statin intolerance.
Storage and Shelf Life
Store Clivas 20 in a cool, dry place away from moisture and sunlight. Keep the tablets in their original packaging to protect them from environmental factors. Check the expiration date on the packaging and do not use the medication beyond that date.
Packaging Description
Clivas 20 is available in packs containing 30 coated tablets, each tablet marked with the dosage strength of 20 mg. The packaging is designed to ensure the stability and integrity of the tablets throughout their shelf life.
Clinical Evidence and Proven Effectiveness
Rosuvastatin, the active ingredient in Clivas 20, has been extensively studied in clinical trials. Research has demonstrated the efficacy of rosuvastatin in significantly reducing LDL cholesterol and triglyceride levels while increasing HDL cholesterol levels. Additionally, studies suggest that rosuvastatin may offer benefits beyond lipid-lowering, such as reducing inflammation and improving endothelial function, which are crucial for cardiovascular health.
